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- W2363479955 abstract "Objective To investigate the effects of methylprednisolone(MP)on pressural injury of spinal cord occurred during a surgical operation. Methods Twenty-seven SD rats were randomly divided into three groups. Rats in the experimental group were given with MP at a dose of 30 mg/kg intravenously 3 hours before operation and were given with a maintenance dosage of 5.4 mg/kg·h while in the control group, MP was injected into rats 3 hours after operation with the same dosage and same mode as the experimental group. In the blank group,rats were treated with physiological saline. Incomplete injuries were caused by direct striking against spinal cord with a magnitude of 25 g·cm, Histologic changes of the damaged spinal cord were observed under light microscope on the 8th, 16th, 24th hour respectively after striking. Results Histologic changes of the damaged spinal cord in the rats treated with MP were found to be much less than those in the blank group, and similar results were found in rats of the experimental group compared with those in the control group. Conclusion MP could protect the spinal cord from damages occurred during surgical operations and the effects could be enhanced by a dosage of MP using before operation." @default.
- W2363479955 created "2016-06-24" @default.
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- W2363479955 date "2006-01-01" @default.
- W2363479955 modified "2023-09-23" @default.
- W2363479955 title "Histologic Changes of the Effects of Methylprednisolone(MP) on Pressural Injury of Spinal Cord Occurred During a Surgical Operation" @default.
- W2363479955 hasPublicationYear "2006" @default.
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