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- W2363485136 abstract "[Objective] To describe HIV-1 transmission within a family through clinical,epidemiological and molecular investigation to identify the transmission relationships among family members. [Methods] To investigate the risk factors for intrafamilial transmission of HIV-1 infection through qualitative epidemiology,to comprehensively analyze the HIV-1 pol and env gene which were amplified by nest RT-PCR,sequenced and phylogenetically analyzed and to compare with the data from clinical epidemiological survey. [Results] The subtype of HIV-1 of all three people of the family was CRF 07-BC.Phylogenetic analysis of the three people was as high as 98%-99%.The diversity of genetic clone was insignificant.The genetic relation was established among the parents' genetic clone,furthermore the son's genetic relation with the father was much higher than that with mother,and the drug resistance associated mutations of three patients were basically similar,other than A71T.The mutation rates at A71T of the son and father were 100% and 83% respectively,while no mutation happened in the mother.[Conclusion] In this family,the mother was infected by the father's part of the viruses which had not mutated,whilst the son was infected by the father's mutated virus.This study preliminarily revealed that the HIV transmission is due to intimate personal exposure among this family." @default.
- W2363485136 created "2016-06-24" @default.
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- W2363485136 date "2007-01-01" @default.
- W2363485136 modified "2023-09-24" @default.
- W2363485136 title "A molecular epidemiological study on HIV-1 transmission within a family" @default.
- W2363485136 hasPublicationYear "2007" @default.
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