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- W2363491656 abstract "Objective:To explore the relationship between Ghrelin and insulin-IGF axis and the effect to the growth and development and energy metabolism in newborn. Methods:62 newborn were divided into preterm infant,term infant,SGA infant and AGA infant groups according to the gestational age and birth weight.14 cases were 30~34 weeks gestational age,14 cases were 34+1~37 weeks gestational age,and 34 cases were 37+1~41 weeks gestational age.In term group,13 cases were SGA infants and 21 cases were AGA infants.The concentration of Ghrelin,IGF-1,IGFBP-3,insulin and glucose were measured and compared and correlation analyzed in all the subjects. Results:The concentration of plasma Ghrelin in 30~34 weeks group,34+1~37 weeks group and 37+1~41 weeks group was(2.238±0.618)ng/ml,(1.226±0.37)ng/ml,(1.036±0.328)ng/ml respectively.It was much higher in preterm infant than in the term infant(P0.000 1).Furthermore,the higher the gestational age,the smaller the difference.The concentration of IGF-1 was(43.214±16.723) ng/ml,(115.579±30.136)ng/ml,(153.292±26.633)ng/ml respectively.The concentration of IGFBP-3 was(70.814±22.603)ng/ml,(123.300±28.666)ng/ml,(157.214±38.990)ng/ml respectively.The concentration of insulin was(1.032±0.812)μU/ml,(5.534±2.273)μU/ml,(14.654±3.064)μU/ml respectively.The concentration of IGF-1,IGFBP-3 and insulin in preterm infant were lower than in the term infant(P0.0001).The concentration of plasma Ghrelin in SGA was higher than in AGA in term infant(1.996±0.294(ng/ml) 1.036±0.328(ng/ml))(P0.0001).The concentration of IGF-1,IGFBP-3 and insulin in SGA infant were lower than in AGA infant(IGF-1:68.479±19.489(ng/ml) 153.292±26.633(ng/ml);IGFBP-3:47.662±17.642(ng/ml) 157.214±38.99(ng/ml);insulin:3.898±2.289(μU/ml) 14.654±3.064(μU/ml))(P0.000 1).The concentration of glucose were no significant difference in all groups(P0.05).The correlation analysis in SGA group and AGA group showed negative correlation between Ghrelin and IGF-1,IGFBP-3 and insulin(in AGA group r=-0.831 1,P0.000 1;r=-0.713,P0.001;r=-0.688,P0.001;in SGA group r=-0.654,P0.05;r=-0.737,P0.05;r=-0.964,P0.000 1). Conclusion:There are insulin-IGF axis lesion in SGA infant.The concentration of IGF-1 and insulin are low,that lead to the concentration of Ghrelin increasing,to compensate the negatively balance." @default.
- W2363491656 created "2016-06-24" @default.
- W2363491656 creator A5070252116 @default.
- W2363491656 date "2011-01-01" @default.
- W2363491656 modified "2023-09-25" @default.
- W2363491656 title "The concentration of plasma Ghrelin,IGF-1,IGFBP-3 and Insulin in newborn with different gestational age and birth weight" @default.
- W2363491656 hasPublicationYear "2011" @default.
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