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- W2363492638 abstract "Objective To underlying investigate the mechanisms of the aging induced by D-galactose,we used D-galactose to establish aging rat model.Methods Aging rats model were established by peritoneal injection of D-Galactose(100 mg/kg,56 days)into the rats.Then,we examined spatial memory with the morris water maze,and the extent of oxidative stress biomarkers including malondialdehyde(MDA),total antioxidative capabilities(T-AOC),total superoxide dismutase(T-SOD),and glutathione peroxidase(GSH-Px)activities in hippocampus.Results Chronic systemic exposure of D-galactose to rats induced a spatial memory deficit and increased cerebral oxidative stress,including an increase in malondialdehyde(MDA),hydrogen peroxide(H2O2),nitric oxide(NO),while a decrease in total anti-oxidative capabilities(T-AOC),total superoxide dismutase(T-SOD),glutathione(GSH),glutathione peroxidase(GSH-Px),glutathione-s-transferase(GSH-ST)activities.Conclusion The present results suggest that chronic D-galactose exposure can induce a spatial memory deficit and aging of central nervous system by manipulating thiol antioxidants and NO of the hippocampus in rats." @default.
- W2363492638 created "2016-06-24" @default.
- W2363492638 creator A5064859065 @default.
- W2363492638 date "2009-01-01" @default.
- W2363492638 modified "2023-09-26" @default.
- W2363492638 title "D-galactose Regulates Thiol Antioxidants and Induces Aging in Rats" @default.
- W2363492638 hasPublicationYear "2009" @default.
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