FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2363493332> ?p ?o ?g. }

• W2363493332 abstract "The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a structure that is known to have major effects on substrate selectivity in class A β-lactamases, we expressed, purified and kinetically characterized this novel variant. Our results show that compared with GES-116 × His, GES-226 × His displays more efficient hydrolysis of penicillins, and aztreonam, but a loss of efficiency against ceftazidime. In addition, the M169L substitution confers on GES-22 more efficient hydrolysis of the mechanistic inhibitors clavulanic acid and sulbactam. These effects are highly similar to other mutations at the homologous position in other class A β-lactamases, suggesting that this methionine has a key structural role in aligning active site residues and in substrate selectivity across the class." @default.
• W2363493332 created "2016-06-24" @default.
• W2363493332 creator A5000037137 @default.
• W2363493332 creator A5007827494 @default.
• W2363493332 creator A5016164351 @default.
• W2363493332 creator A5016677044 @default.
• W2363493332 creator A5071449566 @default.
• W2363493332 creator A5075247723 @default.
• W2363493332 date "2016-05-11" @default.
• W2363493332 modified "2023-10-16" @default.
• W2363493332 title "Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation" @default.
• W2363493332 cites W1963513281 @default.
• W2363493332 cites W1971602630 @default.
• W2363493332 cites W1974465988 @default.
• W2363493332 cites W2001589497 @default.
• W2363493332 cites W2025930267 @default.
• W2363493332 cites W2027339965 @default.
• W2363493332 cites W2036411010 @default.
• W2363493332 cites W2042022353 @default.
• W2363493332 cites W2046681103 @default.
• W2363493332 cites W2055140709 @default.
• W2363493332 cites W2074631079 @default.
• W2363493332 cites W2083974126 @default.
• W2363493332 cites W2101398331 @default.
• W2363493332 cites W2101741583 @default.
• W2363493332 cites W2121254474 @default.
• W2363493332 cites W2121738061 @default.
• W2363493332 cites W2123214148 @default.
• W2363493332 cites W2131673842 @default.
• W2363493332 cites W2131946678 @default.
• W2363493332 cites W2132329502 @default.
• W2363493332 cites W2134781576 @default.
• W2363493332 cites W2136044296 @default.
• W2363493332 cites W2140920107 @default.
• W2363493332 cites W2143855976 @default.
• W2363493332 cites W2146370566 @default.
• W2363493332 cites W2155472094 @default.
• W2363493332 cites W2159435953 @default.
• W2363493332 cites W2168409658 @default.
• W2363493332 doi "https://doi.org/10.1038/ja.2016.48" @default.
• W2363493332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5106332" @default.
• W2363493332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27168312" @default.
• W2363493332 hasPublicationYear "2016" @default.
• W2363493332 type Work @default.
• W2363493332 sameAs 2363493332 @default.
• W2363493332 citedByCount "2" @default.
• W2363493332 countsByYear W23634933322019 @default.
• W2363493332 countsByYear W23634933322020 @default.
• W2363493332 crossrefType "journal-article" @default.
• W2363493332 hasAuthorship W2363493332A5000037137 @default.
• W2363493332 hasAuthorship W2363493332A5007827494 @default.
• W2363493332 hasAuthorship W2363493332A5016164351 @default.
• W2363493332 hasAuthorship W2363493332A5016677044 @default.
• W2363493332 hasAuthorship W2363493332A5071449566 @default.
• W2363493332 hasAuthorship W2363493332A5075247723 @default.
• W2363493332 hasBestOaLocation W23634933321 @default.
• W2363493332 hasConcept C181199279 @default.
• W2363493332 hasConcept C185592680 @default.
• W2363493332 hasConcept C18903297 @default.
• W2363493332 hasConcept C2776858809 @default.
• W2363493332 hasConcept C2776968632 @default.
• W2363493332 hasConcept C2777289219 @default.
• W2363493332 hasConcept C2777637488 @default.
• W2363493332 hasConcept C2778478555 @default.
• W2363493332 hasConcept C2779454058 @default.
• W2363493332 hasConcept C2779631663 @default.
• W2363493332 hasConcept C2779708577 @default.
• W2363493332 hasConcept C2780120296 @default.
• W2363493332 hasConcept C2780416669 @default.
• W2363493332 hasConcept C2910641391 @default.
• W2363493332 hasConcept C501593827 @default.
• W2363493332 hasConcept C523546767 @default.
• W2363493332 hasConcept C54355233 @default.
• W2363493332 hasConcept C552990157 @default.
• W2363493332 hasConcept C55493867 @default.
• W2363493332 hasConcept C61234307 @default.
• W2363493332 hasConcept C71240020 @default.
• W2363493332 hasConcept C86803240 @default.
• W2363493332 hasConcept C94665300 @default.
• W2363493332 hasConceptScore W2363493332C181199279 @default.
• W2363493332 hasConceptScore W2363493332C185592680 @default.
• W2363493332 hasConceptScore W2363493332C18903297 @default.
• W2363493332 hasConceptScore W2363493332C2776858809 @default.
• W2363493332 hasConceptScore W2363493332C2776968632 @default.
• W2363493332 hasConceptScore W2363493332C2777289219 @default.
• W2363493332 hasConceptScore W2363493332C2777637488 @default.
• W2363493332 hasConceptScore W2363493332C2778478555 @default.
• W2363493332 hasConceptScore W2363493332C2779454058 @default.
• W2363493332 hasConceptScore W2363493332C2779631663 @default.
• W2363493332 hasConceptScore W2363493332C2779708577 @default.
• W2363493332 hasConceptScore W2363493332C2780120296 @default.
• W2363493332 hasConceptScore W2363493332C2780416669 @default.
• W2363493332 hasConceptScore W2363493332C2910641391 @default.
• W2363493332 hasConceptScore W2363493332C501593827 @default.
• W2363493332 hasConceptScore W2363493332C523546767 @default.
• W2363493332 hasConceptScore W2363493332C54355233 @default.
• W2363493332 hasConceptScore W2363493332C552990157 @default.
• W2363493332 hasConceptScore W2363493332C55493867 @default.
• W2363493332 hasConceptScore W2363493332C61234307 @default.
• W2363493332 hasConceptScore W2363493332C71240020 @default.

• next