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- W2363531698 abstract "Kidney targeted gene transfer has been a realistic goal for many researchers since 1991,but unfortunately,so far there has been no reliable gene transfer technique for gene therapy of renal diseases.However,at the experimental level,several in vivo gene transfer methods have attempted to target certain renal structures,for example,the HVJ-liposome method and renal perfusion of adenovirus for glomerular cells.Since retroviral vectors require replicating cells for transduction and adenovirus based vectors tend to induce immune reactions,liposome-gene delivery system appears to be an ideal method for gene therapy targeted to the kidney.The intravenous route is not efficient for gene transfer targeted to the kidney,particularly to the tubules,because most of the DNA is trapped in the pulmonary.Gene therapy is a potential treatment modality for tissue and endothelial cells.SUZUKI groups confirm that Glc-S-C8 can act as a renal targeting vector." @default.
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- W2363531698 date "2009-01-01" @default.
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- W2363531698 title "Strategies of gene transfer to the kidney" @default.
- W2363531698 hasPublicationYear "2009" @default.
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