Matches in SemOpenAlex for { <https://semopenalex.org/work/W2363534068> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2363534068 abstract "Objective;To investigate the effect of canstatin on growth,metastasis and angiogenesis of transplanted Lewis lung cancer in mice.Methods:The recombinant pCMV-Script/canstatin vector or the empty vector was transfected into A549 cells by electroporation,and the positive clones were screened with G418.The expressions of canstatin mRNA and protein in transfected A549 cells were examined by RT-PCR and Western blotting,respectively.Furthermore,transplanted Lewis lung cancer mouse model was established,and therapeutic effect of supernatant of pCMV-Script/canstatin transfected A549 cells on transplanted Lewis lung cancer was observed.Microvessel density of transplanted tumors in different therapy groups was observed by immunohistochemistry.Results:Positive clones of A549 cells transfected with pCMV-Script/canstatin were successfully obtained by G418 screening,and could effectively express canstatin mRNA and protein.The tumor size of the pCMV-Script/canstatin group(1.47±0.21 cm ) was significantly smaller than that in the pCMV-Scrip group(2.43±0.15 cm ) and NS group(2.53±0.18 cm )(P0.01).The number of pulmonary metastatic nodes was 3.00±1.00,7.80±1.48 and 7.60±2.41 respectively for pCMV-Script/canstatin,pCM V-Script and NS groups,so pCMV-Script/canstatin significantly inhibited metastasis of tumors(P 0.01).The amount of microvessel count(MVC) in pCMV-Script/canstatin group was markedly decreased compared to that of pCMV-Script and NS groups (P 0.01).Conclusion;The pCMV-Script/canstatin mediates expression of canstatin in A549 cells.Canstatin in A549 supernantant has a strong inhibitory effect on growth,metastasis and angiogenesis of Lewis lung carcinoma." @default.
- W2363534068 created "2016-06-24" @default.
- W2363534068 creator A5076013894 @default.
- W2363534068 date "2011-01-01" @default.
- W2363534068 modified "2023-09-22" @default.
- W2363534068 title "Canstatin inhibits growth,metastasis and angiogenesis of transplanted Lewis lung cancer in mice" @default.
- W2363534068 hasPublicationYear "2011" @default.
- W2363534068 type Work @default.
- W2363534068 sameAs 2363534068 @default.
- W2363534068 citedByCount "0" @default.
- W2363534068 crossrefType "journal-article" @default.
- W2363534068 hasAuthorship W2363534068A5076013894 @default.
- W2363534068 hasConcept C121608353 @default.
- W2363534068 hasConcept C126322002 @default.
- W2363534068 hasConcept C142724271 @default.
- W2363534068 hasConcept C153911025 @default.
- W2363534068 hasConcept C203014093 @default.
- W2363534068 hasConcept C204232928 @default.
- W2363534068 hasConcept C2776256026 @default.
- W2363534068 hasConcept C2779013556 @default.
- W2363534068 hasConcept C2780394083 @default.
- W2363534068 hasConcept C502942594 @default.
- W2363534068 hasConcept C54009773 @default.
- W2363534068 hasConcept C54355233 @default.
- W2363534068 hasConcept C71924100 @default.
- W2363534068 hasConcept C81729549 @default.
- W2363534068 hasConcept C81885089 @default.
- W2363534068 hasConcept C86803240 @default.
- W2363534068 hasConceptScore W2363534068C121608353 @default.
- W2363534068 hasConceptScore W2363534068C126322002 @default.
- W2363534068 hasConceptScore W2363534068C142724271 @default.
- W2363534068 hasConceptScore W2363534068C153911025 @default.
- W2363534068 hasConceptScore W2363534068C203014093 @default.
- W2363534068 hasConceptScore W2363534068C204232928 @default.
- W2363534068 hasConceptScore W2363534068C2776256026 @default.
- W2363534068 hasConceptScore W2363534068C2779013556 @default.
- W2363534068 hasConceptScore W2363534068C2780394083 @default.
- W2363534068 hasConceptScore W2363534068C502942594 @default.
- W2363534068 hasConceptScore W2363534068C54009773 @default.
- W2363534068 hasConceptScore W2363534068C54355233 @default.
- W2363534068 hasConceptScore W2363534068C71924100 @default.
- W2363534068 hasConceptScore W2363534068C81729549 @default.
- W2363534068 hasConceptScore W2363534068C81885089 @default.
- W2363534068 hasConceptScore W2363534068C86803240 @default.
- W2363534068 hasLocation W23635340681 @default.
- W2363534068 hasOpenAccess W2363534068 @default.
- W2363534068 hasPrimaryLocation W23635340681 @default.
- W2363534068 hasRelatedWork W2078358071 @default.
- W2363534068 hasRelatedWork W2239700864 @default.
- W2363534068 hasRelatedWork W2348413630 @default.
- W2363534068 hasRelatedWork W2351343550 @default.
- W2363534068 hasRelatedWork W2352071164 @default.
- W2363534068 hasRelatedWork W2352301690 @default.
- W2363534068 hasRelatedWork W2352735759 @default.
- W2363534068 hasRelatedWork W2354510049 @default.
- W2363534068 hasRelatedWork W2354666437 @default.
- W2363534068 hasRelatedWork W2359949185 @default.
- W2363534068 hasRelatedWork W2363523548 @default.
- W2363534068 hasRelatedWork W2368695975 @default.
- W2363534068 hasRelatedWork W2375481860 @default.
- W2363534068 hasRelatedWork W2377395313 @default.
- W2363534068 hasRelatedWork W2382127924 @default.
- W2363534068 hasRelatedWork W2384241033 @default.
- W2363534068 hasRelatedWork W2384296600 @default.
- W2363534068 hasRelatedWork W2384475376 @default.
- W2363534068 hasRelatedWork W2387459698 @default.
- W2363534068 hasRelatedWork W2391817231 @default.
- W2363534068 isParatext "false" @default.
- W2363534068 isRetracted "false" @default.
- W2363534068 magId "2363534068" @default.
- W2363534068 workType "article" @default.