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- W2363548880 abstract "Objective To study the levels of pro-inflammatory tumor necrosis factor alpha (TNF-α) and interleukin 17 (IL-17) in the supernatant which was from monocyte cell line cultured by the serum of patients with migraine in vitro,and study the effect of nuclear factor kappa B (NF-κB) inhibitor on the two pro-inflammatory cytokines.Methods Serums were collected from 40 migraine patients at the headache period and 40 normal persons (control group). Monocyte cell line THP-1 was cultured in 10% fetal calf serum plus 1640 medium which contained 100 U/ml penicillin and 100 μg/ml streptomycin. The THP-1 cells were divided into 3 groups: normal control group,patient’s serum group and patient’s serum + NF-κB inhibitor BAY11-7082 group. After the cells had been cultured for 24 hrs the levels of TNF-α and IL-17 were measured using ELISA.Results After the cells been cultured for 24 hrs the serum levels of TNF-α and IL-17 in the culture supernatant of the THP-1 cells from the migraineur group were higher than those from the control group (P0.05). The levels of TNF-α from the patient’s serum + BAY11-7082 group were lower than the patient’s serum group (P0.05) and were similar to the normal control group. The levels of IL-17 in the patient’s serum + BAY11-7082 group were lower than those in the patient’s serum group,but there were no significant differences. Compared with the normal control group,the levels of IL-17 in the patient’s serum + BAY11-7082 group increased significantly (P0.05). The correlation analysis revealed that TNF-α levels were significantly positively correlated with IL-17 levels in all of the three groups.Conclusions At the stage of migraine attacks NF-κB might promote the secretion of pro-inflammatory factors TNF-α and IL-17 in patients with migraine." @default.
- W2363548880 created "2016-06-24" @default.
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- W2363548880 date "2010-01-01" @default.
- W2363548880 modified "2023-09-25" @default.
- W2363548880 title "Effect of NF-κB inhibitor on the levels of pro-inflammatory TNF-α and IL-17 in the normal monocyte cell line cultured by the serum of patients with migraine" @default.
- W2363548880 hasPublicationYear "2010" @default.
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