FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2363549322> ?p ?o ?g. }

• W2363549322 endingPage "e0155220" @default.
• W2363549322 startingPage "e0155220" @default.
• W2363549322 abstract "Lipocalin 2 (LCN2) is a secretory protein that is involved in various physiological processes including iron transport. We previously identified LCN2 as an up-regulated gene in endometrial carcinoma, and found that the overexpression of LCN2 and its receptor, SLC22A17, was associated with a poor prognosis. However, the functions and mechanism of action of LCN2 currently remain unclear.The LCN2-overexpressing endometrial carcinoma cell lines, HHUA and RL95-2, and LCN2-low-expressing one, HEC1B, were used. The effects of LCN2 on cell migration, cell viability, and apoptosis under various stresses, including ultraviolet (UV) irradiation and cisplatin treatment, were examined using the scratch wound healing assay, WST-1 assay, and Apostrand assay, respectively.LCN2-silencing using shRNA method significantly reduced the migration ability of cells (p<0.05). Cytotoxic stresses significantly decreased the viability of LCN2-silenced cells more than that of control cells. In contrast, LCN2 overexpression was significantly increased cisplatin resistance. These effects were canceled by the addition of the iron chelator, deferoxamine. After UV irradiation, the expression of phosphorylated Akt (pAkt) was decreased in LCN2-silenced cells, and the PI3K inhibitor canceled the difference induced in UV sensitivity by LCN2. The cisplatin-induced expression of pAkt was not affected by LCN2; however, the expression of p53 and p21 was increased by LCN2-silencing.These results indicated that LCN2 was involved in the migration and survival of endometrial carcinoma cells under various stresses in an iron-dependent manner. The survival function of LCN2 may be exerted through the PI3K pathway and suppression of the p53-p21 pathway. These functions of LCN2 may increase the malignant potential of endometrial carcinoma cells." @default.
• W2363549322 created "2016-06-24" @default.
• W2363549322 creator A5004983606 @default.
• W2363549322 creator A5012556516 @default.
• W2363549322 creator A5015641530 @default.
• W2363549322 creator A5020222131 @default.
• W2363549322 creator A5021381255 @default.
• W2363549322 creator A5028206707 @default.
• W2363549322 creator A5032733918 @default.
• W2363549322 creator A5033185576 @default.
• W2363549322 creator A5036833876 @default.
• W2363549322 creator A5056625451 @default.
• W2363549322 date "2016-05-11" @default.
• W2363549322 modified "2023-10-02" @default.
• W2363549322 title "Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells" @default.
• W2363549322 cites W1588950918 @default.
• W2363549322 cites W1851477634 @default.
• W2363549322 cites W1967539432 @default.
• W2363549322 cites W1973018184 @default.
• W2363549322 cites W1975984713 @default.
• W2363549322 cites W1982633483 @default.
• W2363549322 cites W1991381877 @default.
• W2363549322 cites W1995118176 @default.
• W2363549322 cites W1999979744 @default.
• W2363549322 cites W2004682964 @default.
• W2363549322 cites W2019695784 @default.
• W2363549322 cites W2021503386 @default.
• W2363549322 cites W2027159479 @default.
• W2363549322 cites W2033955020 @default.
• W2363549322 cites W2036124167 @default.
• W2363549322 cites W2053023199 @default.
• W2363549322 cites W2055646855 @default.
• W2363549322 cites W2059030377 @default.
• W2363549322 cites W2067092430 @default.
• W2363549322 cites W2072410309 @default.
• W2363549322 cites W2073361927 @default.
• W2363549322 cites W2074692187 @default.
• W2363549322 cites W2081279867 @default.
• W2363549322 cites W2083968819 @default.
• W2363549322 cites W2086145454 @default.
• W2363549322 cites W2089646327 @default.
• W2363549322 cites W2094112735 @default.
• W2363549322 cites W2098896133 @default.
• W2363549322 cites W2105366115 @default.
• W2363549322 cites W2106981708 @default.
• W2363549322 cites W2117631891 @default.
• W2363549322 cites W2119607431 @default.
• W2363549322 cites W2119747788 @default.
• W2363549322 cites W2123583425 @default.
• W2363549322 cites W2138063658 @default.
• W2363549322 cites W2152863656 @default.
• W2363549322 cites W2158093626 @default.
• W2363549322 cites W2169296803 @default.
• W2363549322 cites W2169515379 @default.
• W2363549322 cites W2183423932 @default.
• W2363549322 cites W2345846009 @default.
• W2363549322 cites W2395990959 @default.
• W2363549322 cites W2414203970 @default.
• W2363549322 cites W563812826 @default.
• W2363549322 doi "https://doi.org/10.1371/journal.pone.0155220" @default.
• W2363549322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4864227" @default.
• W2363549322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27168162" @default.
• W2363549322 hasPublicationYear "2016" @default.
• W2363549322 type Work @default.
• W2363549322 sameAs 2363549322 @default.
• W2363549322 citedByCount "29" @default.
• W2363549322 countsByYear W23635493222016 @default.
• W2363549322 countsByYear W23635493222017 @default.
• W2363549322 countsByYear W23635493222018 @default.
• W2363549322 countsByYear W23635493222019 @default.
• W2363549322 countsByYear W23635493222020 @default.
• W2363549322 countsByYear W23635493222021 @default.
• W2363549322 countsByYear W23635493222022 @default.
• W2363549322 countsByYear W23635493222023 @default.
• W2363549322 crossrefType "journal-article" @default.
• W2363549322 hasAuthorship W2363549322A5004983606 @default.
• W2363549322 hasAuthorship W2363549322A5012556516 @default.
• W2363549322 hasAuthorship W2363549322A5015641530 @default.
• W2363549322 hasAuthorship W2363549322A5020222131 @default.
• W2363549322 hasAuthorship W2363549322A5021381255 @default.
• W2363549322 hasAuthorship W2363549322A5028206707 @default.
• W2363549322 hasAuthorship W2363549322A5032733918 @default.
• W2363549322 hasAuthorship W2363549322A5033185576 @default.
• W2363549322 hasAuthorship W2363549322A5036833876 @default.
• W2363549322 hasAuthorship W2363549322A5056625451 @default.
• W2363549322 hasBestOaLocation W23635493221 @default.
• W2363549322 hasConcept C104317684 @default.
• W2363549322 hasConcept C119056186 @default.
• W2363549322 hasConcept C126322002 @default.
• W2363549322 hasConcept C134018914 @default.
• W2363549322 hasConcept C137738243 @default.
• W2363549322 hasConcept C173396325 @default.
• W2363549322 hasConcept C185592680 @default.
• W2363549322 hasConcept C190232843 @default.
• W2363549322 hasConcept C190283241 @default.
• W2363549322 hasConcept C20299238 @default.
• W2363549322 hasConcept C2776694085 @default.
• W2363549322 hasConcept C2778239845 @default.

• next