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- W2363552355 abstract "AIM:To observe the extent of infarct and the variations of partial pressure of brain tissue oxygen (PbtO2) around the infracted zone after permanent middle cerebral artery occlusion (MCAO) in rabbits with hyperbaric oxygen preconditioning (HBOP) and hypobaric hypoxia preconditioning (HHP). METHODS: Seventy-two male rabbits were randomly divided into 3 groups: simple MCAO group (n=24), HBOP+MCAO group (100% O2, 2.5 ATA, 1 h/d, 5 d, n=24) and HHP+MCAO group (4000 m, 61.6 kPa, 3 d, n=24). The signal intensity of MRI, infarct size and PbtO2 were detected at 1, 3 and 10 d after permanent MCAO. RESULTS: Compared with the simple MCAO group, the abnormal signal zone of T2WI in MRI which indicated ischemia and the TTC staining which indicated infarcted size reduced significantly at 3 and 10 d after permanent MCAO. The Signal intensity ratio (SIR) in the simple MCAO group were (1.83±0.07), (1.36±0.06) at 3 and 10 d after permanent MCAO, which were significantly decreased after HBOP[(1.62±0.09), (1.17±0.10)] and HHP [(1.64±0.06), (1.20±0.09)] (P0.05).PbtO2 around the infracted regions in the simple MCAO group were (7.03±1.06), (8.43±0.86), and (11.83±1.28) mmHg at 1, 3 and 10d after permanent MCAO, which were significantly increased after HBOP and HHP (P0.05). After permanent MCAO, the PbtO2 were (8.27±0.58), (11.92±1.27), and (16.12±1.42) mmHg in HBOP group, and (8.46±0.90), (10.77±1.19), and (15.33±1.29) mmHg in HHP group. CONCLUSION: HBOP and HHP have an preventional and therapic effect on focal cerebral ischemia after permanent MCAO in rabbits." @default.
- W2363552355 created "2016-06-24" @default.
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- W2363552355 date "2007-01-01" @default.
- W2363552355 modified "2023-09-23" @default.
- W2363552355 title "Preventive and therapeutic effects of hyperbaric oxygen and hypobaric hypoxia preconditioning on cerebral infarction after permanent middle cerebral artery occlusion in rabbits and its mechanism" @default.
- W2363552355 hasPublicationYear "2007" @default.
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