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- W2363553359 abstract "[Objective]To investigate the expressions of HIF-1α and cyclinE in osteosarcoma and their relationships with biological characteristics and prognostic value. [Method]The expressions of HIF-1αand cyclinE were examined by SP Immunohistochemical staining in 36 osteosarcoma tissues.The profile was correlated with clinicopathologic parameters and prognosis.[Result](1)The positive rate and average value of positive label index of HIF-1αand cyclinE was [61.6%(22/36),(19.64±8.78)、55.6%(20/36),(19.20±9.27)]respectively;(2) The expression conformation rate of HIF-1αand cyclinE was 65.8%,and there was a statistically significant positive correlation between expressions of HIF-1α and cyclinE(r=0.7435,P﹤0.05);(3) The positive intensity of HIF-1α and cyclinE expressions correlated with cell differentiation of osteosarcoma closely(P﹤0.05);(4) The positive intensity of HIF-1α expressions in patients with tumor metastasis was higher than that in patients without metastasis(P﹤0.01);(5)Univariate and multivariate survival analysis indicated that high expressions of HIF-1αand cyclinE correlated with poor prognosis of patients with osteosarcoma(P﹤0.05).[Conclusion]With the increase in degree of malignancy,The high expressions of HIF-1αand cyclinE protein may participate in the malignant progression of osteosarcoma,their cojoined detection have a definite value in judging prognosis in osteosarcoma." @default.
- W2363553359 created "2016-06-24" @default.
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- W2363553359 date "2008-01-01" @default.
- W2363553359 modified "2023-09-27" @default.
- W2363553359 title "Expressions of hypoxia-inducible factor-1α and cyclinE in osteosarcoma and their prognostic significance" @default.
- W2363553359 hasPublicationYear "2008" @default.
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