Matches in SemOpenAlex for { <https://semopenalex.org/work/W2363571018> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2363571018 endingPage "9" @default.
- W2363571018 startingPage "147" @default.
- W2363571018 abstract "To study the clinical efficacy and safety of lamivudine in the treatment of chronic hepatitis B.72 patients with hepatitis B were randomly assigned into lamivudine (n = 54) and placebo groups (n = 18) for 12 weeks. Then, all the patients received lamivudine 100 mg daily until week 104. Clinical symptoms, liver function tests, serum HBV DNA and YMDD mutation were evaluated.HBV DNA response rate of lamivudine group was higher than that of placebo group after 12 weeks treatment (61% vs 6%, P < 0.01). ALT sustained normalization rate of lamivudine group was higher than that of placebo group (65% vs 11%, P < 0.05). At week 52 and week 104, HBV DNA response rate was 78% and 36% respectively, whereas the normalization rate of ALT was 39% and 33% respectively. Proportion of HBeAg/anti-HBe seroconversion was both 6.1% at week 52 and 104. Overall YMDD mutation rate was 13.7% at week 52 and 39.7% at week 104. The incidence of adverse effects was similar for lamivudine and placebo group at week 12. There was no severe drug-related adverse events during 104 weeks treatment.Lamivudine 100 mg daily could suppress HBV replication rapidly and be well tolerated. However, in some cases, YMDD mutation may lead to HBV DNA breakthrough." @default.
- W2363571018 created "2016-06-24" @default.
- W2363571018 creator A5009931030 @default.
- W2363571018 creator A5051013571 @default.
- W2363571018 creator A5091780779 @default.
- W2363571018 date "2001-06-01" @default.
- W2363571018 modified "2023-09-23" @default.
- W2363571018 title "[Clinical efficacy of lamivudine in the treatment of chronic hepatitis B]." @default.
- W2363571018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11436644" @default.
- W2363571018 hasPublicationYear "2001" @default.
- W2363571018 type Work @default.
- W2363571018 sameAs 2363571018 @default.
- W2363571018 citedByCount "1" @default.
- W2363571018 crossrefType "journal-article" @default.
- W2363571018 hasAuthorship W2363571018A5009931030 @default.
- W2363571018 hasAuthorship W2363571018A5051013571 @default.
- W2363571018 hasAuthorship W2363571018A5091780779 @default.
- W2363571018 hasConcept C126322002 @default.
- W2363571018 hasConcept C142724271 @default.
- W2363571018 hasConcept C159047783 @default.
- W2363571018 hasConcept C197934379 @default.
- W2363571018 hasConcept C204787440 @default.
- W2363571018 hasConcept C2522874641 @default.
- W2363571018 hasConcept C27081682 @default.
- W2363571018 hasConcept C2775940106 @default.
- W2363571018 hasConcept C2777382497 @default.
- W2363571018 hasConcept C2777410769 @default.
- W2363571018 hasConcept C2777451964 @default.
- W2363571018 hasConcept C2777869810 @default.
- W2363571018 hasConcept C2780593183 @default.
- W2363571018 hasConcept C2992208098 @default.
- W2363571018 hasConcept C3020491458 @default.
- W2363571018 hasConcept C71924100 @default.
- W2363571018 hasConcept C90924648 @default.
- W2363571018 hasConceptScore W2363571018C126322002 @default.
- W2363571018 hasConceptScore W2363571018C142724271 @default.
- W2363571018 hasConceptScore W2363571018C159047783 @default.
- W2363571018 hasConceptScore W2363571018C197934379 @default.
- W2363571018 hasConceptScore W2363571018C204787440 @default.
- W2363571018 hasConceptScore W2363571018C2522874641 @default.
- W2363571018 hasConceptScore W2363571018C27081682 @default.
- W2363571018 hasConceptScore W2363571018C2775940106 @default.
- W2363571018 hasConceptScore W2363571018C2777382497 @default.
- W2363571018 hasConceptScore W2363571018C2777410769 @default.
- W2363571018 hasConceptScore W2363571018C2777451964 @default.
- W2363571018 hasConceptScore W2363571018C2777869810 @default.
- W2363571018 hasConceptScore W2363571018C2780593183 @default.
- W2363571018 hasConceptScore W2363571018C2992208098 @default.
- W2363571018 hasConceptScore W2363571018C3020491458 @default.
- W2363571018 hasConceptScore W2363571018C71924100 @default.
- W2363571018 hasConceptScore W2363571018C90924648 @default.
- W2363571018 hasIssue "2" @default.
- W2363571018 hasLocation W23635710181 @default.
- W2363571018 hasOpenAccess W2363571018 @default.
- W2363571018 hasPrimaryLocation W23635710181 @default.
- W2363571018 hasRelatedWork W2087416757 @default.
- W2363571018 hasRelatedWork W2094536182 @default.
- W2363571018 hasRelatedWork W2137544368 @default.
- W2363571018 hasRelatedWork W2352344800 @default.
- W2363571018 hasRelatedWork W2361783070 @default.
- W2363571018 hasRelatedWork W2363757513 @default.
- W2363571018 hasRelatedWork W2370748364 @default.
- W2363571018 hasRelatedWork W2385782763 @default.
- W2363571018 hasRelatedWork W2405403554 @default.
- W2363571018 hasRelatedWork W3149671881 @default.
- W2363571018 hasVolume "15" @default.
- W2363571018 isParatext "false" @default.
- W2363571018 isRetracted "false" @default.
- W2363571018 magId "2363571018" @default.
- W2363571018 workType "article" @default.