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- W2363577497 abstract "Nicotinic acetylcholine receptor (nChRs) are involved in the various pharmacological effects or disease states, such as Alzheimer's Disease, Parkinson's Disease, or tobacco addiction. A new procedure for synthesis of 6--A-85380, a PET maging agent for Nicotinic Acetylcholine Receptor is described. 6--A-85380 is prepared by using trimethylammonium as a leaving group from the precursor, 6-[-N(CH 3) + 3I -]-A-85380, which is synthesized with commercial 2-bromo-3-pyridinol and (S)-2-azetidinecarboxylic acid as starting materials. The whole procedure for radiosynthesis is executed in 50～55min and 38%～48% of the added 18F are found in the purified 6--A-85380 , with specific activity of (0.74～1.85)×10 11Bq/μmol." @default.
- W2363577497 created "2016-06-24" @default.
- W2363577497 creator A5084589573 @default.
- W2363577497 date "2002-01-01" @default.
- W2363577497 modified "2023-09-25" @default.
- W2363577497 title "Synthesis and Labeling of a Precursor for Imaging Nicotinic Acetylcholine Receptors" @default.
- W2363577497 hasPublicationYear "2002" @default.
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