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- W2363596719 abstract "Objective Cancer metastasis involves multiple genes and their products.Metastasis-associated-gene 1(MTA1) is a newly discovered cancer metastasis-related gene.This study was to explore the relationship of MTA1 expression in non-small cell lung cancer(NSCLC) with the clinicopathological profiles of the patient and determine its value in predicting the metastasis potential and clinical prognosis of NSCLC.Methods Using immunohistochemical staining,we detected the expression of MTA1 in the NSCLC tissue samples of 96 patients with complete follow-up data.Meanwhile,we analyzed the clinicopathological profiles and evaluated their correlation with metastasis potential and prognosis of NSCLC.Results The expression of MTA1 exhibited significant differences in NSCLC among tumors of different diameters(d)(d≤3 cm: 54.5%,d≤5 cm: 93.3%,d 5 cm: 81.8%,χ2 = 13.898,P = 0.001),TNM stages(stageⅠ: 53.8%,stage Ⅱ: 46.7%,stage Ⅲ: 89.1%,stage Ⅳ: 81.8%,χ2 = 15.348,P = 0.002),differentiation degrees(high and moderate: 61.5%,low and anaplastic: 81.4%,χ2 = 4.117,P = 0.042),and between lymph node metastasis and non-lymph node metastasis(59.1% vs 81.1%,χ2 = 4.501,P = 0.034),but not among different age and gender groups and pathological types(P 0.05).The Kaplan-Meiert survival curve showed the 2-year the progress-free survival(PFS) rates to be 8.2% and 30.4% in the NSCLC patients with highly and lowly expressed MTA1,respectively(P = 0.007).COX multivariate analysis indicated that high MTA1 expression,TNM staging and lymph node metastasis were independent risk factors for the prognosis of NSCLC.Conclusion MTA1 is highly expressed in NSCLC,and is closely associated with the metastasis and prognosis of lung cancer." @default.
- W2363596719 created "2016-06-24" @default.
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- W2363596719 date "2013-01-01" @default.
- W2363596719 modified "2023-09-25" @default.
- W2363596719 title "Expression of MTA1 protein in non-small cell lung cancer and its association with the prognosis of the disease" @default.
- W2363596719 hasPublicationYear "2013" @default.
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