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- W2363600502 abstract "To study relationship of the HIV from the disease progressors and one isolated from long - term survivors (LTS). Method HIV- 1 isolation was done by co-culture with peripheral blood mononuclear cells (PBMC) from the positive and negetive individuals. Viral antigen p24 of the cultural supernatants was used as a maker of the viral replication. Results (1)4 HIV- 1 strains were isolated from 15 LTS (26.7% ), and 14 ones from 20 HIV- 1 infected progressors in the same area (70% ); (2) The rate of viral isolation was obviously related to the numbers of CD4 + cells, the lower of CD4 cells, the higher the rate of the viral isolation. The viral isolation was also obviously increased by exclusion of CD8 + cells in co-culture; (3) The viral strains isolated from LTS grew slowly with a low titer in vitro without syncytia and could not replicate in T cell lines. Sequence analysis also shown that the isolated strains were non-synctyium (NSI) type; (4)The biological features of the most strains from the progressors were silimar with those from LTS. Conclusion No obvious difference in biological features is found between the LTS and the most of progressor strains. Therefore, It is possible that viro-logical factor is not a key factor affecting the disease progression." @default.
- W2363600502 created "2016-06-24" @default.
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- W2363600502 date "2000-01-01" @default.
- W2363600502 modified "2023-09-25" @default.
- W2363600502 title "Viral Isolation from Long - term Survivors with HIV - 1 Infections and Analysis of the Viral Biological Features in Southwest of China" @default.
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