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- W2363614149 abstract "OBJECTIVE To investigate the effect of cherry freeze-dried powder on swelling of hind paw of gouty arthritis rats induced by monosodium urate ( MSU) and inflammation, and study the possible mechanism. METHODS 40 male Wistar rats were involved. The rats were divided randomly into four groups (the control group, the model group, the low-dose group and the high-dose group), 10 rats each group. The control group and model group were given basic diet, and the low-dose group and the high -dose group were given diets containing 10g / kg and 20g / kg ( cherry freeze -dried powder weight / diet weight) cherry freeze-dried powder respectively, for 8 weeks. 50μl monosodium urate (5%) was injected into the right hind paw of rats to establish gouty arthritis model. 6 hours later, the paws swelling of rats were measured, the contents of NO and PGE 2 of paws and the contents of IL-6 and TNF-α in blood were tested. RESULTS The hind paw swelling of rats were inhib- ited by both cherry powder group (compared with model group, P﹤0.05). The contents of NO and PGE 2 of swelling paws and the contents of IL-6 and TNF-α in blood were significantly lower (compared with model group, P﹤0.05). CONCLUSION Cherry freeze-dried powder can release the swelling of hind paw of gouty arthritis rats induced by monosodium urate , and can inhibit the proinflammatory factors of IL-6 and TNF-α to reduce inflammation factors of PGE 2 and NO." @default.
- W2363614149 created "2016-06-24" @default.
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- W2363614149 date "2013-01-01" @default.
- W2363614149 modified "2023-09-26" @default.
- W2363614149 title "The anti-inflammatory effect of cherry freeze-dried powder on rats with gouty arthritis" @default.
- W2363614149 hasPublicationYear "2013" @default.
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