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- W2363615063 abstract "Objective:To detect the HER-2 expression at the protein and gene level, compare the examining method between IHC and FISH,and analyze clinical application. Methods:To detect the HER-2 protein expression and the gene amplification with immunohistochemistry and fluorescence in situ hybridization respectively. Results: HER-2 protein detection with IHC:in 77 women with breast infiltrating ductal carcinoma,the negative[(-)-(+)]accounted for 35.06%,(++)37.66%,(+++)27.27%.HER-2 gene amplification detection with FISH,positive rate was 51.95%.The group with IHC(+++) had the FISH positive rate of 90.48%,the group with IHC(++) had the FISH positive rate of 68.97% and the group with IHC[(-)-(+)]had the FISH positive rate of 3.07%,with significant difference (P0.01).If we considerde HER-2 gene amplification as positive standard,result with IHC(+++)had the positive predictive value of 90.48%,sensitivity of 95.00% and specificity of 92.86%,result with IHC(++)had the positive predictive value of 68.97%,sensitivity of 95.24% and specificity of 74.29%,result with IHC[(-)-(+)]had the negative predictive value of 96.30%. Conclusion: Overexpression of HER-2 protein was a result of its HER-2 gene amplification,IHC (+++) and IHC [(-)-(+)] could give an advise on clinical medication.Result with IHC (++) needs FISH tesc to determine whether the gene had amplification furthermore." @default.
- W2363615063 created "2016-06-24" @default.
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- W2363615063 date "2009-01-01" @default.
- W2363615063 modified "2023-09-23" @default.
- W2363615063 title "The detection of HER-2 protein and gene in the human breast cancer and its clinical significance" @default.
- W2363615063 hasPublicationYear "2009" @default.
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