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- W2363640214 abstract "Objective:To investigate the regulation of paecilomyces cicadae (P. cicadae) on immunological function in normal and immunosuppressive rats.Methods:After different groups of rats were administered with corresponding drugs by subcutaneous injection for 26 days, the wet weight of spleen and thymus were measured and their weight indexes were calculated,the activities of acid phosphatase (ACP) and lactate dehydrogenase (LDH) in serum, liver, spleen, kidney and thymus were determined by biochemical methods, and the shape and structure of splenic macrophages (MΦ)were observed with electron microscope.Results:After P. cicadae was administered to rats, the following results were observed: The spleen weight (splenic weight indexes) increased remarkably in normal rats(P0.001 or P0.01) and immunological organs (spleen and thymus) atrophy induced by Cy were inhibited significantly (P0.05 orP0.01).The ACP activities in kidney and LDH activities in thymus of normal rats were enhanced significantly(P0.05), and the decrease of the activities of ACP and LDH in liver, spleen, kidney, and thymus of Cy immunosuppressed rats was repressed evidently(P0.05 or P0.01 or P0.001).Under electron microscope the splenic MΦ showed auxetic growth, and the number of lysosomes in MΦ cytoplasm and the gibbosity on the MΦ surface increased evidently in normal rats.Conclusion:P.cicadae can activate immune system and antagonize the immunosuppressive effects of cyclophamide." @default.
- W2363640214 created "2016-06-24" @default.
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- W2363640214 date "2002-01-01" @default.
- W2363640214 modified "2023-09-25" @default.
- W2363640214 title "The experimental study of paecilomyces cicadae relieving immunosuppressed effect due to cyclophosphamide" @default.
- W2363640214 hasPublicationYear "2002" @default.
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