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- W2363640235 abstract "[Purpose] To investigate KAI1/CD82 and VEGF expressions and their relationship with clinicopathological profile and postoperative recurrence in small hepatocellular carcinoma (SHCC). [Methods] Expression of CD82 and VEGF was determined by immunohistochemistry technique (S-P method) in 40 cases of SHCC tissue, 35 cases of SHCC adjacent liver tissue, 5 cases of hepatic adenoma tissue and 5 cases of normal liver tissue from liver angioma. The expressions with the clinicopathological profile and survival were analyzed. [Results] Positive expression rate of CD82 protein in SHCC was 40% (16/40), which was significantly lower than that in the normal liver tissue from liver angioma (100%, 5/5), hepatic adenoma tissue (100%, 5/5), SHCC adjacent liver tissue (100%, 35/35) (P0.05). The positive expression rate of VEGF protein in SHCC was 85% (34/40), which was significantly higher than that in the normal liver tissue from liver angioma (40%, 2/5) and SHCC adjacent liver tissue (42.8%, 15/35) (P0.05). There was no expression correlation between CD82 and VEGF. The recurrence rate in CD82 negative SHCC group was 54.2%, which was significantly higher than that in CD82 positive SHCC group (18.8%) (P=0.026). The 1,2,3-year cumulative disease-free survival rates in CD82 positive SHCC group were 94%, 87%, 68%, those were higher than those in CD82 negative SHCC group (85%, 78%, 43% respectively). The recurrence rate in VEGF positive SHCC group was 47.1%, which was significantly higher than that in VEGF negative SHCC group(0) (P=0.035). The sensitivity and specificity of combined testing of CD82 and VEGF for diagnosing the recurrence of SHCC were 81.3% and 62.5% respectively. [Conclusion] The expressions of CD82 and VEGF were correlated to recurrence of SHCC. CD82 might become a predictive marker for the recurrence of SHCC." @default.
- W2363640235 created "2016-06-24" @default.
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- W2363640235 date "2007-01-01" @default.
- W2363640235 modified "2023-09-26" @default.
- W2363640235 title "Expressions Relationship Between CD82 and VEGF and Postoperative Recurrence in Small Hepatocellular Carcinoma" @default.
- W2363640235 hasPublicationYear "2007" @default.
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