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- W2363645051 abstract "Objective To study the in vitro activity of cefuroxime/tazobactam combined at various ratios(1∶1、2∶1、4∶1)、cefoperazone/shubatan、piperacillin/tazobactam against clinical isolates,in order to provide the evidence for the new drug research of drug manufactory.Methods MIC were determined by the two fold agar dilution,β-lactamase by nitrocefin slip.Results MIC of cefuroxime/tazobactam against 97 clinical isolates(with % β-lactamase)were measured,which were isolated between January 2005 and January 2006.The vitro activity against gram positive gucci was significantly enhanced by various ratios combined use of cefuroxime/tazobactam,except methicillin resistant staphylococcus(MRS).the enzyme inhibitor of tazobactam has significantly enhanced the antibacterial activities of cefuroxime,the MIC90 of cefuroxime/tazobactam(1∶1) were dereased to256μg/ml-32μg/ml、256μg/ml-64μg/ml、256μg/ml-128μg/ml、256μg/ml-128μg/ml,the resistance rate were obviously decreased.The vitro activity against gram positive coccus were significantly enhanced by various ratios combined use of cefuroxime/tazobactam,except to methicillin resistant staphylococcus aures(MRSA).The best antibacterial activity of cefuroxime/tazobactam was achieved in the ratio of (1∶1).Conclusion the combination of cefuroxime/tazobactam(1∶1)is an significant bactericidal medicine." @default.
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- W2363645051 date "2009-01-01" @default.
- W2363645051 modified "2023-09-24" @default.
- W2363645051 title "In vitro antibacterial activities of cefurixime/tazobactam against clinical isolates gram positive gucci." @default.
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