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- W2363659276 abstract "To study the characteristics of full-length Hepatitis B Virus(HBV) genomes isolated from HBeAg positive chronic hepatitis B(CHB) patients.Amplified the full-length HBV genomes by PCR from the serum of HBeAg positive CHB patients,sequenced and analyzed the structure of HBV genomes.Obtained twenty-three full-length HBV DNAs from the different CHB patients.Phylogenetic analysis revealed that all HBV strains could be categorized into genotype B or C.Structural analysis showed that,as compared to standard strains of Chinese HBV B、C subtypes,HBV obtained shared meaningful consensus mutations in B/T cell epitopes of surface and P protein,transactive domain of X protein and enhancer II/core promoter regions.Genotype and gene mutation of HBV may closely correlated with the carcinogenesis of HBV-related chronic hepatitis B." @default.
- W2363659276 created "2016-06-24" @default.
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- W2363659276 date "2011-01-01" @default.
- W2363659276 modified "2023-09-26" @default.
- W2363659276 title "Structural analysis of 23 full-length hepatitis B virus genomes isolated from HBeAg positive chronic hepatitis B patients" @default.
- W2363659276 hasPublicationYear "2011" @default.
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