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- W2363660150 abstract "OBJECTIVE:To investigate the effect of Apaf-1 in progression of NSCLC (non- small cell lung cancer,NSCLC). METHODS:The expression of Apaf-1 gene and methylation of Apaf-1(apoptotic protease activating factor-1) promoter were analyzed by immunohistochemical, RT-PCR and methylation specific PCR (MSP) in 45 NSCLC tumor tissues and normal lung tissues. RESULTS: Apaf-1 gene expression was obviously down-regulated in 60%(27/45) of NSCLC,P=0.000 5. Nineteen cases of Apaf-1 gene methylation were detected in 27 cases with obvious down-regulation expression of Apaf-1,but 5 cases methylation were found in 18 cases in which the expression of Apaf-1 gene had no obvious change. The difference of the two groups had statistical significance,P=0.005. No methylation was found in 45 normal lung tissues. CONCLISION:This study confirmed the association between Apaf-1 gene and NSCLC,and DNA methylation in promoter region participates in the decreased expression of Apaf-1 gene in NSCLC." @default.
- W2363660150 created "2016-06-24" @default.
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- W2363660150 date "2006-01-01" @default.
- W2363660150 modified "2023-09-27" @default.
- W2363660150 title "Study on expression and promoter methylation of Apaf-1 gene in non-small cell lung cancer" @default.
- W2363660150 hasPublicationYear "2006" @default.
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