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- W2363661739 abstract "Antitumor antibiotics B-599 Ⅲ iso-lated from the fermentation broth of pre-viously reported S. fulvorectus n. sp. hasbeen separated into five components, (Ⅰ),(Ⅱ), (Ⅲ), (Ⅳ) and (Ⅴ), by solventextraction and subsequent fractionationon silica gel column chromatography. Theprincipal component (Ⅲ) is an acidicgolden yellow powdered substance, whichis soluble in methanol, ethanol, acetone,ethyl acetate and butyl acetate, slightlysoluble in benzene, ether and tetrachloro-methane, but insoluble in water andpetroleum ether. It gives positive reac-tions with ferric chloride, Molisch, Fehlingand alkali H_2O_2 solution. It has themolecular formula C_(57)H_(82)O_(21), m.p. 183℃(d), [α]_D~(23)-53.3°(C=1, in ethanol), itsUV spectra showes peaks λ_(max)~(EtOH) 229, 280,306, 332, and 412 μm; E_(1cm)~(1%) 265, 542, 72,95, 70, and 104; and the IR spectrumv_(cm)~(KBr)-1 3410 (OH), 1745 (C=O), 1645,(C=O, conjugated carbonyl), 1595, 1528(Arom.), 1258 (Acetyl), 1078 (--O--).On the basis of NMR spectrum analysis, ithas been also proved to be consistent withChromomycin A_3. On hydrolysis with 50% aqueousacetic acid at 75°for 3 hr., component(111) gives the four sugars, chromoses A,B, C and D, and the aglycone chromomy-cinone, which has light yellowish needlecrystals, C_(21)H_(24)O_9, m. p. 176—178℃, anda hexaacetate m. p. 183℃, was also ob-tained. The mass spectral studies werecarried out with aglycone. A small peakat m/e 420 and a stronger one at 272 maybe assigned as the molecular-ion peakand base peak, respectively, while otherfour peaks at m/e 60, 358, 376 and402 correspond to the C_2H_4O_2, C_(19)H_(18)O_7,C_(19)H_(20)O_8 and C_(21)H_(22)O_8 fragments. From the physical and chemical pro-perties of the parent compound, hydro-lysis product, as well as their derivativesindicated above, the identity of component(Ⅲ) with known Chromomycin A_3 hasbeen confirmed." @default.
- W2363661739 created "2016-06-24" @default.
- W2363661739 creator A5001845324 @default.
- W2363661739 date "1974-01-01" @default.
- W2363661739 modified "2023-09-25" @default.
- W2363661739 title "STUDIES ON THE ANTITUMOR ANTIBIOTICS B-599-III II. ISOLATION AND IDENTIFICATION OF CHROMOMYCIN A_3" @default.
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