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- W2363665598 abstract "Objective To explore the effect of Erbin deficiency in MDA-453 cells on trastuzumab( Herceptin) resistance. Methods The specific short hairpin RNA( shRNA) targeting Erbin was designed and cloned into plasmid pSuppressor,which was subsequently transfected into MDA-453 human breast cancer cells. After being selected by G418,MDA-453 cells stably expressing Erbin shRNA were obtained and nominated as MDA-453-Erbin sh. The MDA-453 cells expressing control shRNA( MDA-453-NC) were used as control cells. The expression of Erbin at the protein level in MDA-453-NC and MDA-453-Erbin sh cells was analyzed by Western blotting. Cell proliferation and colony formation assays were employed to investigate the effect of Erbin knockdown on the sensitivity of MDA-453 cells to trastuzumab in vitro. The levels of Erbin expression in human breast cancer tissue and normal breast tissue samples were evaluated by immunohistochemistry.Results MDA-453 cells,in which Erbin expression was stably knocked-down,were established. Deficiency of Erbin in MDA-453 cells could antagonize the anti-proliferation effects of trastuzumab in vitro. The level of Erbin expression was decreased in some breast cancer tissue samples compared with normal breast tissue samples. Conclusion Erbin deficiency may induce the resistance of breast cancer cells to trastuzumab therapy." @default.
- W2363665598 created "2016-06-24" @default.
- W2363665598 creator A5073494173 @default.
- W2363665598 date "2013-01-01" @default.
- W2363665598 modified "2023-09-23" @default.
- W2363665598 title "Deficiency of Erbin in MDA-453 human breast cancer cells induces trastuzumab resistance in vitro" @default.
- W2363665598 hasPublicationYear "2013" @default.
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