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- W2363670011 abstract "Objective To investigate the antitumor effect of EgrEndostatin gene combined with radioactive drug-colloidal 32P inhibitory on the rat liver.Methods After gene and colloidal 32 P were injected into liver cancer,the growth rate of liver cancer were measured at 7 d,14 d,21 d.Microvessel density determination(MVD)and apoptosis index(AI) were be measured at 21 d.Results Compared with the control the indexs in the treatment groups had significant difference index(P0.05-0.01).The inhibitory effect of 32 P+ Egr-Endostatin is the best(P0.01).In the term of liver cancer growth rate,there are not significant difference between the 32 P group,Endostatin gene and Egr-Endostatin gene group in antitumor effect at 7 d-14 d,(P0.05);But at 21 d,the treatment effect of 32 P group is clearly down.In terms of MVD,compared with the control group the treatment group has obvious statistical difference(P0.01);compared with the other treatment group,32P group has statistical difference(P0.01);32 P+Endostatin group has statistical comparing with other groups(P0.01).In terms of AI index,the control group has statistical difference comparing with treatment groups(P0.01);32P group also has difference comparing with Endostatin group and Egr-Endostatin group(P0.05);AI index of 32 P+Endostatin group and 32 P+Egr-Endostatin is better than other treatment groups(P0.05-0.01).Conclusion Colloidal 32 P combining Egr-Endostatin gene plays the important role in treating liver cancer.32P can create the radiation function,Egr-1 can induce expression enhancement of Endostatin and the Endostatin Gene can inhibit liver tumor angiogenesis.Therefore the whole effect of the three factors can manifestly decrease the liver cancer growing." @default.
- W2363670011 created "2016-06-24" @default.
- W2363670011 creator A5052590910 @default.
- W2363670011 date "2010-01-01" @default.
- W2363670011 modified "2023-09-27" @default.
- W2363670011 title "Radioactive Drugs and Egr-endostatin Synergistic Antitumor Effect" @default.
- W2363670011 hasPublicationYear "2010" @default.
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