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- W2363670380 abstract "Objective To observe the effect of Aitongping on c-fos gene expression and substance P(SP) content in spinal dorsal horn of rats with formalin-induced pain.Methods Fifty SD rats were randomized into 5 groups: blank control group,model group,tramadol group(0.06g/kg),high-and low-dose Aitongping groups(36 and 18g/kg respectively).Rats model of pain was induced by subcutaneous injection of formalin into the plantar surface of the left hind paw of rats.The fos gene expression and SP content were observed in superficial lamella of spinal dorsal horn of spinal section from the lumbar vertebrae L3 to L5 by immunohistochemical method.Results The number of neurons with fos gene expression positive and the optical density(D value) of reactants with SP expression positive were increased in the model group(P0.01 compared with the blank control group),and high -dose Aitongping had a counteraction on the above indexes(P0.01 compared with the model group).Conclusion The analgesic mechanism of Aitongping is probably through decreasing the reaction of spinal dorsal horn to noxious stimulus." @default.
- W2363670380 created "2016-06-24" @default.
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- W2363670380 date "2009-01-01" @default.
- W2363670380 modified "2023-09-25" @default.
- W2363670380 title "Effect of Aitongping on c-fos Gene Expression and Substance P Content in Spinal Dorsal Horn of Rats with Formalin-induced Pain" @default.
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