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• W2363670442 abstract "<h3>Background</h3> Pneumococcal conjugate vaccine (PCV7) is directed against the 7 most common serotypes of Streptococcus pneumoniae (Sp) causing invasive diseases. It has potential coverage for 57-85% of Sp serotypes causing acute otitis media (AOM). PCV7 reduces AOM incidence by 6-8% and reduces Sp- AOM by 34%. PCV7 may prevent AOM through reduction of nasopharyngeal (NP) colonization of vaccine serotypes of Sp; studies have shown this finding in healthy infants after PCV7 vaccination. No study compares NP bacterial colonization during AOM in the pre- and post-PCV7 vaccination eras. <h3>Methods</h3> Children (6 mos.-6 yrs) were enrolled in AOM studies between 9/95 and 5/04. NP swab was obtained at the diagnosis of AOM. Bacterial cultures were performed by standard methods; Sp isolates were not serotyped. <h3>Results</h3> Of 439 subjects, 215 were enrolled prior to PCV7 availability (historical controls); 224 were enrolled after PCV7 licensure: 126 of these were considered underimmunized, 98 were adequately immunized. Overall, Sp was isolated from 49% of cases, nontypeable H. influenzae (NTHi) from 34% and M. catarrhalis (Mc) 60%. NP colonization rate for Sp was not different between the 3 groups. (table) There was no difference in penicillin-resistant Sp (PR-<i>Sp</i>) between groups, but there was a yearly trend for reduction in number and rate of colonization with PR-<i>Sp</i> in children diagnosed during the PCV 7 era. Colonization with NT<i>Hi</i> tended to increase in PCV7 immunized children (<i>p</i> = .19). Colonization with <i>Mc</i> was significantly higher in immunized children (<i>p</i> = .0259). Combining 3 bacteria for each case, the mean number of bacteria in immunized children was significantly higher than controls (<i>p</i> = .05). <h3>Conclusion</h3> In children with AOM, immunization with PCV7 did not reduce <i>Sp</i> colonization in the NP, although there was a trend for reduction in rates of PR-<i>Sp</i>. Increase in colonization by NT<i>Hi</i> and <i>Mc</i> resulted in increased overall NP colonization with pathogenic bacteria. The clinical significance of this finding deserves further investigations." @default.
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• W2363670442 date "2005-01-01" @default.
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• W2363670442 title "258 PNEUMOCOCCAL CONJUGATE VACCINE INCREASED NASOPHARYNGEAL BACTERIAL COLONIZATION IN CHILDREN WITH ACUTE OTITIS MEDIA:" @default.
• W2363670442 doi "https://doi.org/10.2310/6650.2005.00006.257" @default.
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