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- W2363673923 abstract "Objective: The study explored the functions of p70S6Kand 4EBP1 on cardiac hypertrophy after long- term training with different intensity. Methods: Fifty- four male Sprague- Dawley rats aged 7 weeks were randomly divided into nine groups: control group,moderate intensity groups and high intensity groups with myocardium being isolated at four different observing time points after the last bout of exercise training which lasted for 7 weeks. The rats of moderate intensity groups need to exercise 60min with the intensity of 28m / min,while those of high intensity groups need to exercise 60min with the intensity of 38m / min. Both moderate intensity groups and high intensity groups exercise 5 days per week,and rest for 2 days. The protein levels,both the total and phosphorylated forms of p70S6Kand 4EBP1 were detected. Results: The total amounts of p70S6Kand 4EBP1 in both exercise training groups almost remain the same level as the control group. Compared with control group,the phosphorylation of p70S6Kin the moderate group was significantly activated,and reached the peak at 12 hours after the exercise( p 0. 01). Its activated state lasted for 24h after training. But the phosphorylation of p70S6Kin the high intensity group was not activated,and decreased significantly after 24h post- training( p 0. 01). In moderate intensity group,the amount of phosphorylated 4EBP1( Thr37 /46) reached its climax immediately after the last training and significantly higher than control group,while after 24h its value significantly lower than base level( p 0. 01). Conclusions: P70S6K and 4EBP1 were activated after moderate exercise and played important roles in cardiac hypertrophy. The molecular mechanism of cardiac hypertrophy after high intensity exercise might differ from that of moderate group." @default.
- W2363673923 created "2016-06-24" @default.
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- W2363673923 date "2013-01-01" @default.
- W2363673923 modified "2023-09-25" @default.
- W2363673923 title "Regulation of Cardiac Hypertrophy by p70~(S6K) and 4EBP1 after Long Time Exercises of Different Intensities" @default.
- W2363673923 hasPublicationYear "2013" @default.
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