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- W2363676239 abstract "[Objective] To study the influence of copolymer polyethylene glycol (PEG)- polyethylenimine (PEI) composition on gene delivery in vitro. [Methods] The PEG-PEI /DNA complexes were formed with different molecular weights of PEG and degree of PEGylation. The interaction between the positively charged PEI and the negatively charged plasmid DNA was investigated. The complex size and zeta potential of copolymer/DNA complexes were measured, and the cytotoxicity and the transfection efficiency for Hela cells were evaluated. [Results] The PEG side chains had no significant effect on the complex formation and protection of DNA. PEG 5 k significantly reduced the diameter of the complexes. The zeta potential of complexes reduced with increasing degree of PEG grafting. The cytotoxicity of the complexes did not change with molecular weight of PEG, but changed with the degree of PEG substitution; Copolymer PEG-PEI(2-25-1) was proved to be a better carrier for in vitro gene transfer. [Conclusion] The copolymer block structure strongly influences not only the physicochemical properties of the DNA complexes, but also their cytotoxicity and transfection efficiency." @default.
- W2363676239 created "2016-06-24" @default.
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- W2363676239 date "2007-01-01" @default.
- W2363676239 modified "2023-09-28" @default.
- W2363676239 title "Poly(ethylene glycol)-block-polyethylenimine Copolymers as Carriers for Gene Delivery in Vitro" @default.
- W2363676239 hasPublicationYear "2007" @default.
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