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- W2363676329 abstract "[Objective] To validate the immune protective efficacy of Chlamydia secretion protein Pgp3 and to analyze the potential immune mechanisms related to this protection.[Methods] The prokaryotic recombinant protein Pgp3 was purified and evaluated for its protective efficacy in a genital tract infected mouse model.Groups of BALB/c mice were immunized intranasally or intramuscularly with adjuvants plus Pgp3 protein or PBS and GST control.Humoral and cellular immune responses were evaluated.After Chlamydia muridarum intravaginal challenge,the chlamydia shedding from the lower genital tract and the chlamydia-induced upper genital tract gross pathology and histopathological characterization were also detected.[Results] Adjuvant plus Pgp3 immunization can induce high level of Pgp3 specific antibody as well as IFN-γ,IL-17 and IL-5 cytokine production.More importantly,intranasal immunization compare with intramuscular route induced more Th1-dominant immunity that significantly reduced the shedding of live organisms from the lower genital tract and attenuated inflammatory pathologies in the oviduct tissues.[Conculsion] These observations have demonstrated that secretion protein Pgp3 intranasal immunization can induce protective immunity against chlamydial infection and pathology in mice." @default.
- W2363676329 created "2016-06-24" @default.
- W2363676329 creator A5032190382 @default.
- W2363676329 date "2012-01-01" @default.
- W2363676329 modified "2023-09-23" @default.
- W2363676329 title "Intranasal immunization with secretion protein Pgp3 enhances protective immunity against mice genital Chlamydia muridarum infection" @default.
- W2363676329 hasPublicationYear "2012" @default.
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