FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2363676876> ?p ?o ?g. }

• W2363676876 endingPage "631" @default.
• W2363676876 startingPage "616" @default.
• W2363676876 abstract "During liver injury, hepatocytes secrete exosomes that include diverse types of self‐RNAs. Recently, self‐noncoding RNA has been recognized as an activator of Toll‐like receptor 3 (TLR3). However, the roles of hepatic exosomes and TLR3 in liver fibrosis are not yet fully understood. Following acute liver injury and early‐stage liver fibrosis induced by a single or 2‐week injection of carbon tetrachloride (CCl4), increased interleukin (IL)‐17A production was detected primarily in hepatic γδ T cells in wild‐type (WT) mice. However, liver fibrosis and IL‐17A production by γδ T cells were both significantly attenuated in TLR3 knockout (KO) mice compared with WT mice. More interestingly, IL‐17A‐producing γδ T cells were in close contact with activated hepatic stellate cells (HSCs), suggesting a role for HSCs in IL‐17A production by γδ T cells. In vitro treatments with exosomes derived from CCl4‐treated hepatocytes significantly increased the expression of IL‐17A, IL‐1β, and IL‐23 in WT HSCs but not in TLR3 KO HSCs. Furthermore, IL‐17A production by γδ T cells was substantially increased upon coculturing with exosome‐treated WT HSCs or conditioned medium from TLR3‐activated WT HSCs. However, similar increases were not detected when γδ T cells were cocultured with exosome‐treated HSCs from IL‐17A KO or TLR3 KO mice. Using reciprocal bone marrow transplantation between WT and TLR3 KO mice, we found that TLR3 deficiency in HSCs contributed to decreased IL‐17A production by γδ T cells, as well as liver fibrosis. Conclusion: In liver injury, the exosome‐mediated activation of TLR3 in HSCs exacerbates liver fibrosis by enhancing IL‐17A production by γδ T cells, which might be associated with HSC stimulation by unknown self‐TLR3 ligands from damaged hepatocytes. Therefore, TLR3 might be a novel therapeutic target for liver fibrosis. (Hepatology 2016;64:616‐631)" @default.
• W2363676876 created "2016-06-24" @default.
• W2363676876 creator A5003985416 @default.
• W2363676876 creator A5008700592 @default.
• W2363676876 creator A5017735053 @default.
• W2363676876 creator A5020037808 @default.
• W2363676876 creator A5021254648 @default.
• W2363676876 creator A5031789193 @default.
• W2363676876 creator A5032944553 @default.
• W2363676876 creator A5048764161 @default.
• W2363676876 creator A5053783882 @default.
• W2363676876 creator A5067162094 @default.
• W2363676876 creator A5070893822 @default.
• W2363676876 creator A5071928897 @default.
• W2363676876 date "2016-06-29" @default.
• W2363676876 modified "2023-10-18" @default.
• W2363676876 title "Exosome‐mediated activation of toll‐like receptor 3 in stellate cells stimulates interleukin‐17 production by γδ T cells in liver fibrosis" @default.
• W2363676876 cites W1895601060 @default.
• W2363676876 cites W1965938315 @default.
• W2363676876 cites W1976134131 @default.
• W2363676876 cites W1981420342 @default.
• W2363676876 cites W1983629229 @default.
• W2363676876 cites W1986178107 @default.
• W2363676876 cites W2000369852 @default.
• W2363676876 cites W2004315368 @default.
• W2363676876 cites W2005119615 @default.
• W2363676876 cites W2009811042 @default.
• W2363676876 cites W2012680181 @default.
• W2363676876 cites W2014913358 @default.
• W2363676876 cites W2018346422 @default.
• W2363676876 cites W2037555606 @default.
• W2363676876 cites W2037718422 @default.
• W2363676876 cites W2055168309 @default.
• W2363676876 cites W2062410076 @default.
• W2363676876 cites W2070131223 @default.
• W2363676876 cites W2073387472 @default.
• W2363676876 cites W2076996690 @default.
• W2363676876 cites W2080418767 @default.
• W2363676876 cites W2083988704 @default.
• W2363676876 cites W2097639161 @default.
• W2363676876 cites W2099369804 @default.
• W2363676876 cites W2101085816 @default.
• W2363676876 cites W2103999760 @default.
• W2363676876 cites W2104614292 @default.
• W2363676876 cites W2109666345 @default.
• W2363676876 cites W2110115944 @default.
• W2363676876 cites W2116342732 @default.
• W2363676876 cites W2142017607 @default.
• W2363676876 cites W2171925512 @default.
• W2363676876 cites W276689322 @default.
• W2363676876 doi "https://doi.org/10.1002/hep.28644" @default.
• W2363676876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27178735" @default.
• W2363676876 hasPublicationYear "2016" @default.
• W2363676876 type Work @default.
• W2363676876 sameAs 2363676876 @default.
• W2363676876 citedByCount "135" @default.
• W2363676876 countsByYear W23636768762016 @default.
• W2363676876 countsByYear W23636768762017 @default.
• W2363676876 countsByYear W23636768762018 @default.
• W2363676876 countsByYear W23636768762019 @default.
• W2363676876 countsByYear W23636768762020 @default.
• W2363676876 countsByYear W23636768762021 @default.
• W2363676876 countsByYear W23636768762022 @default.
• W2363676876 countsByYear W23636768762023 @default.
• W2363676876 crossrefType "journal-article" @default.
• W2363676876 hasAuthorship W2363676876A5003985416 @default.
• W2363676876 hasAuthorship W2363676876A5008700592 @default.
• W2363676876 hasAuthorship W2363676876A5017735053 @default.
• W2363676876 hasAuthorship W2363676876A5020037808 @default.
• W2363676876 hasAuthorship W2363676876A5021254648 @default.
• W2363676876 hasAuthorship W2363676876A5031789193 @default.
• W2363676876 hasAuthorship W2363676876A5032944553 @default.
• W2363676876 hasAuthorship W2363676876A5048764161 @default.
• W2363676876 hasAuthorship W2363676876A5053783882 @default.
• W2363676876 hasAuthorship W2363676876A5067162094 @default.
• W2363676876 hasAuthorship W2363676876A5070893822 @default.
• W2363676876 hasAuthorship W2363676876A5071928897 @default.
• W2363676876 hasBestOaLocation W23636768761 @default.
• W2363676876 hasConcept C104317684 @default.
• W2363676876 hasConcept C126322002 @default.
• W2363676876 hasConcept C134018914 @default.
• W2363676876 hasConcept C145059251 @default.
• W2363676876 hasConcept C176891718 @default.
• W2363676876 hasConcept C185592680 @default.
• W2363676876 hasConcept C20518536 @default.
• W2363676876 hasConcept C2776637226 @default.
• W2363676876 hasConcept C2780559512 @default.
• W2363676876 hasConcept C2781261824 @default.
• W2363676876 hasConcept C55493867 @default.
• W2363676876 hasConcept C71924100 @default.
• W2363676876 hasConcept C86803240 @default.
• W2363676876 hasConcept C95444343 @default.
• W2363676876 hasConceptScore W2363676876C104317684 @default.
• W2363676876 hasConceptScore W2363676876C126322002 @default.
• W2363676876 hasConceptScore W2363676876C134018914 @default.
• W2363676876 hasConceptScore W2363676876C145059251 @default.
• W2363676876 hasConceptScore W2363676876C176891718 @default.
• W2363676876 hasConceptScore W2363676876C185592680 @default.

• next