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- W2363678610 abstract "Objective To investigate the influence of Jiusuyu Suspension on hippocampus acetylcholinesterase (AchE) activity and striatum dopamine (DA) and 5-hydroxytryptamine (5-HT) contentsin acute alcoholism mice.Method The mouse model of acute alcoholism was established by giving Hongxing Erguotou Spirit (containing 56 per cent alcohol) to mice orally. The influence of Jiusuyu Suspension on drunken time, drunken rate, hippocampus AchE activity and striatum contents of DA and 5-HT were observed and compared with Gehuajiecheng Decoction.Result The rats of the model group showed an exciting at the first and repressive manifestations then. The activity of hippocampus AchE and striatum contents of DA and 5-HT in the model group were increased compared with those in the normal group (P0.01). The drunken rate was obviously decreased (P0.05) and drunken time was prolonged (P0.05 or P0.01) in the groups with high or low dose of Jiusuyu Suspension compared with those in the model group. The drunken time was longer in the group with high dose of Jiusuyu Suspension than that in Gehuajiecheng Decoction group (P0.05). The contents of DA and 5-HT were obviously reduced in 3 treatment groups (P0.05 or P0.01). The activity of hippocampus AchE was obviously decreased in the group with high dose of Jiusuyu Suspension and Gehuajiecheng Decoction group (P0.05 or P0.01).Conclusion Jiusuyu Suspension can regulate the contents of brain monoaminergic neurotransmitter (DA, 5-HT) and AchE activity, and relieve the abnormal neurobehaviors of alcoholism." @default.
- W2363678610 created "2016-06-24" @default.
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- W2363678610 date "2007-01-01" @default.
- W2363678610 modified "2023-09-26" @default.
- W2363678610 title "Influence of Jiusuyu Suspension on AchE activity of hippocampus and striatum monamine neurotransmitter content in acute alcoholism mice" @default.
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