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- W2363679140 abstract "Objective To research P-glycoprotein(P-gp) expression of serum and cerebrospinal fluid in Hui and Han people with epilepsy,and to explore the relationship between P-gp expression and epilepsy drug-resistance.Methods 187 cases of epilepsy patients were selected,including 28 cases of Hui sensitive patients and 31 cases of drug resistance patients,59 cases of Han sensitive patients and 69 cases of drug resistance patients.ELISA method was adopted to measure the concentration of P-gp in serum and cerebrospinal fluid.Results Compared with patients in drug resistance groups,P-gp concentration of cerebrospinal fluid and serum,were decreased,as well as the ratio of sensitive group,and the discrepancy were statistically significant(P0.05).The comparison between epilepsy P-gp concentration in cerebrospinal fluid and the ratio of P-gp concentration of cerebrospinal fluid and serum in Hui and Han people was not statistically significant different(P0.05),but the comparison between both of the serum P-gp concentration was statistically significant(P0.05).Conclusion Serum and cerebrospinal fluid in drug-resistant epilepsy patients showed excessive expression of P-gp.It is closely related with epilepsy drug-resistant." @default.
- W2363679140 created "2016-06-24" @default.
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- W2363679140 date "2012-01-01" @default.
- W2363679140 modified "2023-09-24" @default.
- W2363679140 title "Relationship of P-glycoprotein expression of serum and cerebrospinal fluid and epilepsy drug-resistance in Hui and Han People with epilepsy" @default.
- W2363679140 hasPublicationYear "2012" @default.
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