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- W2363702987 abstract "Objective:To study the expression of calcitonin gene-related peptide(CGRP)and CGRPmRNA in trigeminal ganglia(TG)in rats with occlusal reconstruction,and to discuss the mechanism of temporomandibular disorders.Methods:48 Wistar male rats were randomly divided into 3 experimental groups and 3 control groups,with 8 rats in each group.The right molars of maxillary and mandibular of rats in experimental groups were ground to the gingival margin level without occlusal contact.The occlusal contact was recovered by stoping grounding molars of the rats.The section of trigeminal ganglia underwent the immunohistological and situ hybridization study.Light microscope and microscopic photo analysis software were employed to detect the percentage of CGRP and CGRPmRNA positive neurons in frozen section of TGs in 48 rats.SPSS10.0 statistical software was used for statistical analysis.Results:The percentage of CGRP positive neurons in TG of unilateral chewing experimental group was significantly decreased compared with control group(P0.01).The decreased extent on non-chewing side was much higher than that on the chewing side(P0.01).The percentage of CGRPmRNA positive neurons was higher on both chewing and non-chewing sides of the unilateral chewing experimental group than that in control group(P0.01),and that on non-chewing side was much higher than that on the chewing side(P0.01).The result of late-stage occlusal reconstruction experiment group was as same as that of unilateral chewing experimental group.Conclusion:The expressions of CGRP and CGRPmRNA in TG can recover after the early occlusal reconstruction and not after the late-stage occlusal reconstruction.CGRP and CGRPmRNA might participate in the histopathologic mechanism of temporomandibular disorders." @default.
- W2363702987 created "2016-06-24" @default.
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- W2363702987 date "2010-01-01" @default.
- W2363702987 modified "2023-09-26" @default.
- W2363702987 title "Expressions of CGRP and CGRP mRNA in Trigeminal Ganglia in Rats with Occlusal Reconstruction" @default.
- W2363702987 hasPublicationYear "2010" @default.
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