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- W2363703008 abstract "AIM: To observe the special anti EMT6 breast cancer growth effects of the MUC1 gene vaccine. METHODS: Female BALB/c mice were immunized intramuscularly with 100 microgram MUC1 cDNA 3 times at 3 weekly intervals. Three weeks after the last immunization, tumor challenge experiments were performed by using MUC1 expressing tumor cell line EMT6. Tumor growth inhibition and body protection were observed 2 wk later. After 45 d of challenge experiments, all mice were killed and tumors weighted. Histological analysis of tumor tissue was carried out with HE staining. RESULTS: After 45 d of challenge experiments, the volumes of EMT6 tumor in MUC1 cDNA, pcDNA3 1(+), and NS group were respectively (250±24 3) , (596±28 2) and (618±35 6) mm 3( P 0 01). The average masses of EMT6 tumors in those three groups were respectively (1 23±0 41), (2 28±0 66) and (2 36±0 72) g( P 0 01). There was only 40% tumorigenic rate in MUC1 cDNA group, while there was 100% tumorigenic rate in pcDNA3 1(+) and NS groups. It showed that EMT6 tumor growth in mice of MUC1 cDNA group was obviously suppressed ( P 0 01) and there was a significant body protective effect in mice of MUC1 cDNA group ( P 0 05), compared with that in pcDNA3 1(+) control group. Histological analysis showed that the EMT6 tumor tissues markedly necrosed in mice of MUC1 cDNA group compared with that in pcDNA3 1(+) control group. CONCLUSION: MUC1 gene vaccine can significantly suppress the growth of EMT6 breast cancer, which lays a basis for clinical research." @default.
- W2363703008 created "2016-06-24" @default.
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- W2363703008 date "2003-01-01" @default.
- W2363703008 modified "2023-09-26" @default.
- W2363703008 title "Suppressing effect of MUC1 gene vaccine on EMT6 breast cancer growth" @default.
- W2363703008 hasPublicationYear "2003" @default.
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