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- W2363720160 abstract "[Objective] To investigate the injury to peripheral blood in rats with liver embedded-tumor treated by adriamycin and the protective effect of multiple antioxidants. [Methods] The tumor cells (Walker-256) were injected into the rat to create the entity tumor. The entity tumour removed from rat was cut into small pieces for being embedded into the rats' livers. The rats with entity tumor were randomly divided into three groups which were tumor group, chemotherapy group and protective group. The protective group was given antioxidants compound by gavage and other two groups were given the same dosage water. The chemotherapy group and the protective group were given adriamycin by intraperitoneal injection with the dosage of 2 mg/kg body weight every two days. At the eighth week end, all of the animals were killed to measure the changes of peripheral blood components. [Results] Compared with the control group and the tumor group, WBC, LYM%, LYM, RBC, HCT, HGB, MPV of peripheral blood in chemotherapy group decreased significantly (P 0.05), and MON%, GRA%, MON, GRA, MCV, RDW, MCH, PLT, PDW of peripheral blood increased significantly (P 0.05), on which the multiple antioxidants showed remarkable antagonistic effect. [Conclusion] The chemotherapy of the liver tumor with adriamycin can cause injury to peripheral blood in rats, on which the multiple antioxidants have effective protection." @default.
- W2363720160 created "2016-06-24" @default.
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- W2363720160 date "2006-01-01" @default.
- W2363720160 modified "2023-09-24" @default.
- W2363720160 title "Protection of multiple antioxidants on peripheral blood in rats with liver embedded-tumor treated by adriamycin" @default.
- W2363720160 hasPublicationYear "2006" @default.
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