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- W2363732633 abstract "Objective To evaluate the livability and growth of tissue-engineered oral mucosa with scaffold of polyglycolic acid(PGA) and human cadaveric dermis(Alloderm) in vivo. Methods Tissue-engineered oral mucosa were reconstructed by seeding human oral fibroblast(OFC) onto PGA cultured for 7 days,and seeding human oral keratinocytes on PGA-OFC and Alloderm,respectively.They were cultured for 4-7 days submerged and then for another 7 days at air-liquid interface before transplanting into mice.Mice were sacrificed on day 7 and 14 posttransplantation for histological examination. Results Tissue-engineered oral mucosa with scaffolds of PGA and Alloderm could survive in immunodeficient mice for at least two weeks,and integrate with surrounding tissues of the mice.The morphology of epithelia in the former was not evident but with vascularization two weeks posttransplantation,while the latter showed well-balanced epithelia but without distinct vascularization. Conclusion Lacuna of PGA is good for the growth of cells and vessles,but the tenacity reduces with disintegrating.However,the equivalent using Alloderm as scaffold shows better histological fabric." @default.
- W2363732633 created "2016-06-24" @default.
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- W2363732633 date "2006-01-01" @default.
- W2363732633 modified "2023-09-27" @default.
- W2363732633 title "Experiment on Transplanted Tissue-Engineered Oral Mucosa in Mice with Different Scaffolds" @default.
- W2363732633 hasPublicationYear "2006" @default.
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