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- W2363742222 abstract "Objective:Through examining the right atrial appendage organization miR-133 and target genes HCN2 expression in patients with rheumatic heart disease(RHD)and atrial fibrillation(AF),to explore its possible relationship with AF.Method:Ten patients with RHD were divided into AF group(n=5)and sinus rhythm group(SR group,n=5)according to AF or not.The color Doppler ultrasound and ECG were examined preoperative,the right atrial appendage tissue were taken to detect miR-133 and HCN2mRNA expression using real time quantitative poly-merase chain reaction(RT-qPCR).Result:There were significant differences in miR-133 and HCN2expression levels between the SR group and AF group.The miR-133 expression levels of the former was higher than the latter[(0.215 800±0.023 510)vs(0.143 600±0.021 767),P0.05],but the HCN2 mRNA expression levels of the former was lower than the latter[(0.030 40±0.003 29)vs(0.054 20±0.011 45),P0.05].Conclusion:Downregulation of miR-133 upregulate HCN2expression levels in RHD with AF,which may be a correlation with the occurrence of RHD AF." @default.
- W2363742222 created "2016-06-24" @default.
- W2363742222 creator A5017646817 @default.
- W2363742222 date "2014-01-01" @default.
- W2363742222 modified "2023-09-23" @default.
- W2363742222 title "The mechanism of miR-133regulates target genes HCN2 in rheumatic heart disease with atrial fibrillation" @default.
- W2363742222 hasPublicationYear "2014" @default.
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