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- W2363750206 abstract "AIM To evaluate the effect of monoclonal antibody against schistosomula membrane and praziquantel synergically killing schitosoma japonicum. METHODS Experimental Balb/c mice were immunized with the monoclonal antibody (McAb) by peritoneal injection before the challenge and praziquantel 200 mg·kg-1 were given to mice 2h before, and 3 d and 38 d after infection, respectively. The control mice were given praziquantel 200 mg·kg-1 only 2h before, and 3 d and 38 d after infection, respectively. RESULTS The results showed that the worm and egg reduction rates of immunized mice were significant higher than that of the only use praziquantel mice, both in 3 d and 38 d after infection groups. CONCLUSION The difference of worm and egg reduction rates demonstrates that the synergistic action of the McAb and praziquantel existed and immunity to schitosome in the host could significantly enhance the prophylactic activity of praziquantel in animals infected with schistosoma japonicum." @default.
- W2363750206 created "2016-06-24" @default.
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- W2363750206 date "1998-01-01" @default.
- W2363750206 modified "2023-09-23" @default.
- W2363750206 title "Effect of monoclonal antibody against schistosomula membrane and praziquantel synergically killing schistosoma japonicum" @default.
- W2363750206 hasPublicationYear "1998" @default.
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