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- W2363763595 abstract "Objective:To investigate the role of fibrinogen-like protein 2(fgl2) in murine experimental autoimmune hepatitis(EAH) development.Methods:To induce murine EAH,the syngeneic S-100 antigen emulsified in complete Freund’s adjuvant was injected intraperitoneally into adult male C57BL/6 mice.Liver injury was assessed by liver history and serum ALT and AST levels.The expression of fgl2 in livers and spleens of mice was examined by immunohistochemistry staining.The level of serum ALT and expression of fgl2 were measured.To detect whether membrane fgl2 or soluble fgl2 plays an important role in autoimmune hepatitis(AIH),it was examined by Western-blot and dual immunohistochemical staining.Results:In murine models,infiltration of inflammatory cells and foci of necrosis were observed in liver tissues.By immunohistochemistry staining,fgl2 was highly expressed in nonparenchymal cells of liver and spleen tissues in mice with EAH whereas with little or no expression in control mice.Sfgl2 could be expressed and secreted by splenic T-lymphocytes in mice of EAH,but not in normal mice.Conclusion:Soluble fgl2 plays a vital role in an animal model of AIH induced by liver antigen.These results suggested that the sfgl2 expressed by splenic T lymphocytes might be involved in the pathogenesis and development of EAH.These data provide the first evidence to demonstrate that sfgl2 exert effects on EAH by T cells." @default.
- W2363763595 created "2016-06-24" @default.
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- W2363763595 date "2010-01-01" @default.
- W2363763595 modified "2023-09-25" @default.
- W2363763595 title "Expression and function of fgl2 protein in experimental autoimmune hepatitis" @default.
- W2363763595 hasPublicationYear "2010" @default.
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