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- W2363775284 abstract "Objective To compare the intraoperative sedation effect of dexmedetomidine,midazolam and propofol under regional anaesthesia.Methods Seventy-five patients with ASAⅠ~Ⅱ underwent operation on lower limbs under combined spinal-epidural anesthesia(CSEA) were randomly allocated into three groups: Dexmedetomidine group(as group D,n=25),midazolam group(as group M,n=25) and propofol group(as group P,n=25).Dexmedetomidine,midazolam and propofol were administered intravenously to group D,M and P respectively for sedation following CSEA.The Observer's assessment of alertness/sedation scale(OAA/S) were evaluated and reached 3 or 2 points in three groups.Vital signs of BP,HR,ECG and SPO2 were monitored and intraoperative awareness was inquired 24 hours after operation among three groups.Results Sedation and amnesia were satisfied in three groups.There was no statistic difference in awareness rate among three groups(P0.05).Respiration was stable in group D and M,and was slight inhibited in group P;and the respiratory inhibition was happened more easily in group P than in group D or group M(P0.05).The level of BP was risen in 2 patients and declined in 1 patient in group D,was stable in group M and was reduced in 5 patients in group P.Compared with group M,BP of group P was easier to decline(P0.05).HR was decreased obviously in group D,and two patients needed atropine.HR changed slightly in group M and P;so group D had lower HR among three groups(P0.01).Conclusions Used for intraoperative sedation,dexmedetomidine decreased HR significantly and propofol inhibited respiratory and circulative function slightly,but which can be corrected easily.Midazolam had little effect on vital signs.So dexmedetomidine,midazolam or propofol can be safely used for sedation during regional anesthesia." @default.
- W2363775284 created "2016-06-24" @default.
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- W2363775284 date "2012-01-01" @default.
- W2363775284 modified "2023-09-24" @default.
- W2363775284 title "Effect Comparison on Intraoperative Sedation of Dexmedetomidine,Midazolam and Propofol" @default.
- W2363775284 hasPublicationYear "2012" @default.
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