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- W2363779085 abstract "Objective:To study the effects of simvastatin on neonatal cardiac hypertrophy induced by angiotensinⅡ(AngⅡ) and cardiotrophy-1(CT-1) in rat.Method:Simpson’s method was used to culture neonatal rat cardiocytes. Total cells extract were prepared and the total protein content was measured by Lowry’s method. Cell surface area was measured by phase contrast microscope and image analysis system (HJ2000).Result:①Simvastatin (with the dosage 10-6mol/L) inhibited the total protein content and cell surface area of cardiocytes induced by AngⅡsafely and effectually, which was the same as captopril. ②CT-1 increased the total protein content and cell surface area of cardiocytes with dose dependent whereas simvastatin inhibited them.Conclusion:Simvastatin could inhibit the increase of protein content and cell surface area of cardiocytes induced by AngⅡ and CT-1, which could prevent and treat cardiac hypertrophy." @default.
- W2363779085 created "2016-06-24" @default.
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- W2363779085 date "2007-01-01" @default.
- W2363779085 modified "2023-09-28" @default.
- W2363779085 title "Effects of simvastatin on prevention and treatment of cardiac hypertrophy" @default.
- W2363779085 hasPublicationYear "2007" @default.
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