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- W2363786812 abstract "Objective To explore the effect of carnosine in the expression of B cell lymphomal/leukemia-2(bcl-2) andbcl-2-associated X protein(bax) after focal cerebral ischemia in rats. Methods Thirty male SD rats(SPF scale) were ran-domly divided into 3 groups: sham-operated group, model group and carnosine treated group(n=10 for each group). The mid-dle cerebral artery occlusion model(MCAO) was induced in model group and carnosine treated group. Rats were receivedcarnosine [1 000 mg/(kg·d), orally] in carnosine treated group, and the other rats were received the same volume of normal sa-line(NS) in shame-operated group and model group. The neurological deficit score was used to evaluate the neurologicalfunction at 24 h and 72 h after MCAO. Morphological changes were observed by HE staining. TCC staining was used to labelinfarct volume, and immunohistochemistry was used to detect the expression of bcl- 2 and bax. Results Compared withmodel group, the score of neurological function and infarct volume were significantly declined in carnosine treated group at72 h after injury(P0.05 or P0.01). The changes of ischemic impairment were lighter in carnosine treated group than thatof model group. Compared with sham-operated group, the expression levels of bcl- 2 and the ratio of bcl-2/bax were de-creased while the expression of bax was increased in model group(P0.05). Compared with model group, carnosine could sig-nificantly increase the expression of bcl-2 and the ratio of bcl-2/bax, and reduce the expression of bax(P0.01 or P0.05).Conclusion Carnosine can enhance bcl-2 expression, decrease bax expression and increase the ratio of bcl-2/bax, whichis likely to be one of the mechanisms of neuroprotection." @default.
- W2363786812 created "2016-06-24" @default.
- W2363786812 creator A5067934518 @default.
- W2363786812 date "2015-01-01" @default.
- W2363786812 modified "2023-09-23" @default.
- W2363786812 title "The influence of carnosine in expression levels of bcl-2 and bax after focal cerebral ischemia in rats" @default.
- W2363786812 hasPublicationYear "2015" @default.
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