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- W2363798605 abstract "Objective To observe the expression of cytochrome C and apoptosis-related gene BAX in amygdala of depression model rats.Methods Male Wistar rats were randomly divided into control group and model group.Chronic forced swimming stress was carried out to set up the depression model.TUNEL-staining and double-labeled flow cytometry(FCM) were employed for the detection and quantification of the apoptotic cells in the amygdala.The expression of cytochrome C and gene BAX were detected using Western blot and RT-PCR.Results The consumption of sucrose,preference of sucrose,erect quantity and escape latency of model rat were signficantly decreased as compared with that of normal group(P0.01,P0.05).The percentage of TUNEL-positive cell,the apoptotic cell rate and the expression of cytochrome C and gene BAX in model group were higher than those from control group respectively(P0.01).Conclusions Apoptosis is increased in amygdala neurons of depression model rats,and BAX is up-regulated and promotes the releasing of cytochrome C." @default.
- W2363798605 created "2016-06-24" @default.
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- W2363798605 date "2011-01-01" @default.
- W2363798605 modified "2023-09-23" @default.
- W2363798605 title "Increased apoptosis in amygdala neurons of depression model rats" @default.
- W2363798605 hasPublicationYear "2011" @default.
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