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- W2363807682 abstract "In this study,we aimed to explore whether NOD1 signal pathway was activated in the lungs of mice infected with Aspergillus fumigatus(Af).The mice were divided into the normal group and the infected group.The infected mice were sacrificed at time points of 24,48,and 72 h post challenge of Af conidia,while Af burden and pulmonary histopathology were observed at different time points.In infected group,Af burden reached a peak at 48 h and decreased remarkably at 72 h,while severe hyperemia,bleeding and inflammatory cells infiltration were found at 48 h,which were markedly lessened at 72h.But the Af colony was not found and lung tissue structure was normal in normal group.RT-PCR and Western blot showed NOD1 mRNA and RIP2 mRNA expression levels,as well as NF-κBp65 and TNF-αprotein amount were remarkably higher in infected group than those in normal group(P0.05).The highest levels of NOD1 mRNA,RIP2 mRNA,and NF-κBp65 were found at 48 h,while the highest TNF-αlevel was appeared at 72 h (P0.05).Above results demonstrate that NOD1 signal pathway do activated by Af infection in mouse lungs and the innate immunity mediated by NOD1 signal pathway plays a partial role in clearing the fungus and protecting the lung from injury." @default.
- W2363807682 created "2016-06-24" @default.
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- W2363807682 date "2010-01-01" @default.
- W2363807682 modified "2023-09-23" @default.
- W2363807682 title "Activation of NOD1 signal pathway in the lungs of mice infected with Aspergillus fumigatus" @default.
- W2363807682 hasPublicationYear "2010" @default.
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