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- W2363818474 abstract "Objective To study the effect of iodine deficiency or excess on thyroid apoptosis. Methods Animal models of iodine deficiency or excess were established by feeding rats with food from iodine deficient area or water with different level of iodine. Morphology of thyroid was investigated under microscope 20 weeks later. Effect of iodine deficiency or excess on thyroid apoptosis was investigated using transmission electron microscope, TUNEL labeling and immunohistochemical staining, respectively. Results Cell apoptosis of thyroid was markedly increased in iodine deficiency or excess rats. Conclusions Either iodine deficiency or excess may produce thyroid cell apoptosis, and further regulate morphology and function of thyroid, among them the effect of iodine deficiency is stronger. Excess apoptosis may be an important factor of hypothyroidism." @default.
- W2363818474 created "2016-06-24" @default.
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- W2363818474 date "2004-01-01" @default.
- W2363818474 modified "2023-09-25" @default.
- W2363818474 title "Effect of iodine deficiency and excess on thyroid apoptosis in rats" @default.
- W2363818474 hasPublicationYear "2004" @default.
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