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- W2363834331 abstract "Objective To assess the role of the p53 tumor suppressor gene(wild type p53) in G 1 arrest and apoptosis after irradiation in human gastric carcinoma 823 cell lines(BGC823). Methods Three human gastric carcinoma 823 cell lines with different p53 status,i.e.BGC823 wtp53 cells with wild type p53,BGC823 mutp53 cell with mutant p53 alleles and BGC823 vect without p53 gene,were used.Various cell phase distribution and apoptosis were analyzed by flow cytometry in 0,8 and 24h following irradiation with 4Gy. Results The BGC823 wtp53 cells had strong arrest in G 1 phase at 8 and 24h following radiation with 4Gy (67 9% and 61 1% of original population,respectively),while the BGC823 mutp53 and BGC823 vect cells had almost no arrest in G 1 phase at 8 and 24h following radiation with 4Gy.In the BGC823 wtp53 cells,a sub G 1 phase peak of apoptosis could be observed at 8 and 24h after irradiation with 4Gy,apoptotic cell rates being 13 0% and 15 3%,respectively,while the BGC823 mutp53 and BGC823 vect cells had no apoptotic response after irradiation with 4Gy. Conclusion Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation." @default.
- W2363834331 created "2016-06-24" @default.
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- W2363834331 date "1999-01-01" @default.
- W2363834331 modified "2023-09-26" @default.
- W2363834331 title "G 1 arrest and apoptosis of BGC 823 cell lines with different p53 status after irradiation" @default.
- W2363834331 hasPublicationYear "1999" @default.
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