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- W2363860632 abstract "Objective To observe the effects of treating acute ischemic stroke in rats with interventional administration of nitric oxide precurcer L-Arginine or nitric oxide donor nitroglycerin.Methods The right middle cerebral arteries of rats were occluded by insertion of a suture to duplicate ischemia-reperfusion models.Forty-two male SD rats were randomly divided into four groups: MCAO group(n=12);sham operation group(n=6);NG group(n=12) and L-ARG group(n=12),intracarotid arteries administrated respectively by NS、NS、NG and ARG.Each of the four groups were subdivided into 2 groups according to the reperfusion time(3 h and 24 h),measurement of Longa scores,NO2-/NO3-in serum,HE staining and immunohistochemical(SABC)method were utilized to assess the changes of ischemic brain tissues in different groups.Results OX-42 positive cells of cortex and CA3 area of hippocampal: OX-42 positive cells were found,their features identified at 3 h after reperfusion.24 h the response of microglias was obvious,the number of the cells increased(P0.001).NG group 3 h and 24 h,the microglias could be found unclearly,the number was little(P0.05).L-ARG group 3 h and 24 h,the number was also little(P0.05).Conclusion Interventional administration of NO precursor/donator has showed significantprotective function to acute ischemia stroke in rats." @default.
- W2363860632 created "2016-06-24" @default.
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- W2363860632 date "2008-01-01" @default.
- W2363860632 modified "2023-09-26" @default.
- W2363860632 title "Effects of interventional administration of L-Arginine or nitroglycerin on acute local cerebral ischemia in rats" @default.
- W2363860632 hasPublicationYear "2008" @default.
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