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- W2363862021 abstract "Objective To detect the infection of HPV16/18 in external-genitalia squamous cell carcinoma(EGSCC)and explore the relationship of HPV16/18 infection and the expression of PTEN in EGSCC.Methods HPV16/18 DNA was tested in EGSCC and normal tissues by in situ hybridization.Expression of PTEN protein was examined by immunohistochemistry method respectively.The data was analyzed by t'test and Fisher exact probability.Results Except for positive control,there were no infection of HPV16/18 in 31 cases of EGSCC and 15 normal corotrol;The expression rate of PTEN protein in normal tissue was 100.00%(31/31),which was higher than that 38.71%(12/31)in EGSCC(t'=-12.771,P0.05).lower expression of PTEN was correlated with pathological grade.There were no correlation between clinic staging tumor size,lymph node metastasis and patient's age with expression of PTEN.Conclusion The occurence of EGSCC has no correlation with infection of HPV16/18.The infection of HPV16/18 has correlation with some EGSCC.The expression of PTEN protein in normal tissue is more greater than in EGSCC.The lower expression of PTEN in EGSCC is one of mechanisms in pathogenic and development,the expression of PTEN are the marker in EGSCC." @default.
- W2363862021 created "2016-06-24" @default.
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- W2363862021 date "2010-01-01" @default.
- W2363862021 modified "2023-09-26" @default.
- W2363862021 title "Study on the role of PTEN proteins and HPV 16/18 proteins in the pathogenesis of human external genitalia squamous cell carcinoma." @default.
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