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- W2363869562 abstract "OBJECTIVE To study the protective action of 2 methylthiazolidine 4 carboxylic acid (MTCA),thiazolidine 4 carboxylic acid (TCA), N,N diacetylcystine (DAC) and N acetylcysteine (AcCYS) against acute liver failure induced by paracetamol APAP in mice.METHODS The mice were ip APAP 900 mg·kg -1 and then ip MTCA,TCA ,NAC and AcCYS respectively.The blood chemistry (sALT, sAST and TBil),aggregative function and mortality were examined.The concentration of amino acids in plasma were determined by HPLC.The damage of liver tissue was observed by light microscope.RESULTS Administration of four L cysteine prodrugs suppressed the elevation of serum ALT,AST,TBil levels, improved aggregative function and the histopathological changes in varying degree against APAP intoxicated mice.They also corrected the abnormal of plasma amino acid pattern and reduced mortality.CONCLUSION These results demonstrated that the protective effects of MTCA and DAC on APAP induced acute liver failure were superior to that of AcCYS.In contrast,TCA did not show any significant action." @default.
- W2363869562 created "2016-06-24" @default.
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- W2363869562 date "2002-01-01" @default.
- W2363869562 modified "2023-09-25" @default.
- W2363869562 title "Protective effects of four L-cysteine prodrugs on acute liver failure in mice" @default.
- W2363869562 hasPublicationYear "2002" @default.
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